The circadian regulation of food intake
E Challet - Nature Reviews Endocrinology, 2019 - nature.com
Feeding, which is essential for all animals, is regulated by homeostatic mechanisms. In
addition, food consumption is temporally coordinated by the brain over the circadian (~ 24 h) …
addition, food consumption is temporally coordinated by the brain over the circadian (~ 24 h) …
The melanocortin pathway and control of appetite-progress and therapeutic implications
G Baldini, KD Phelan - Journal of Endocrinology, 2019 - joe.bioscientifica.com
The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …
The role of ghrelin and ghrelin signaling in aging
M Amitani, H Amitani, KC Cheng, TS Kairupan… - International Journal of …, 2017 - mdpi.com
With our aging society, more people hope for a long and healthy life. In recent years,
researchers have focused on healthy longevity factors. In particular, calorie restriction delays …
researchers have focused on healthy longevity factors. In particular, calorie restriction delays …
Effects of melanocortin 3 and 4 receptor deficiency on energy homeostasis in rats
P You, H Hu, Y Chen, Y Zhao, Y Yang, T Wang… - Scientific reports, 2016 - nature.com
Abstract Melanocortin-3 and 4 receptors (MC3R and MC4R) can regulate energy
homeostasis, but their respective roles especially the functions of MC3R need more …
homeostasis, but their respective roles especially the functions of MC3R need more …
Inhibition of POMC neurons in mice undergoing activity-based anorexia selectively blunts food anticipatory activity without affecting body weight or food intake
CM Daimon, ST Hentges - American Journal of Physiology …, 2022 - journals.physiology.org
Anorexia nervosa (AN) is a debilitating eating disorder characterized by severely restricted
eating and significant body weight loss. In addition, many individuals also report engaging in …
eating and significant body weight loss. In addition, many individuals also report engaging in …
Mechanisms for AgRP neuron-mediated regulation of appetitive behaviors in rodents
MA Thomas, B Xue - Physiology & behavior, 2018 - Elsevier
The obesity epidemic is a major health and economic burden facing both developed and
developing countries worldwide. Interrogation of the central and peripheral mechanisms …
developing countries worldwide. Interrogation of the central and peripheral mechanisms …
A life without hunger: the ups (and downs) to modulating melanocortin-3 receptor signaling
AA Butler, C Girardet, M Mavrikaki… - Frontiers in …, 2017 - frontiersin.org
Melanocortin neurons conserve body mass in hyper-or hypo-caloric conditions by conveying
signals from nutrient sensors into areas of the brain governing appetite and metabolism. In …
signals from nutrient sensors into areas of the brain governing appetite and metabolism. In …
Alpha-melanocyte-stimulating hormone-mediated appetite regulation in the central nervous system
Q Wu, J Chen, T Hua, J Cai - Neuroendocrinology, 2023 - karger.com
Understanding the complex action mechanism of appetite regulation peptides can
significantly impact therapeutic options in the treatment of obesity and other metabolic …
significantly impact therapeutic options in the treatment of obesity and other metabolic …
Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson's disease mouse model through activating GHS-R1a/D2R heterodimers
T Tang, M Bi, M Diao, X Zhang, L Chen… - Acta Pharmacologica …, 2023 - nature.com
Growth hormone secretagogue receptor 1a (GHS-R1a) is an important G protein-coupled
receptor (GPCR) that regulates a variety of functions by binding to ghrelin. It has been …
receptor (GPCR) that regulates a variety of functions by binding to ghrelin. It has been …
[HTML][HTML] Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss
M Mavrikaki, C Girardet, A Kern, AF Brantley… - Molecular …, 2016 - Elsevier
Objective Appetitive responses to weight loss are mediated by a nutrient-sensing neural
network comprised of melanocortin neurons. The role of neural melanocortin-3 receptors …
network comprised of melanocortin neurons. The role of neural melanocortin-3 receptors …