Essential Oil from Melaleuca leucadendra: Antimicrobial, Antikinetoplastid, Antiproliferative and Cytotoxic Assessment

L Monzote, AM Scherbakov, R Scull, P Satyal, P Cos… - Molecules, 2020 - mdpi.com
Essential oils (EOs) are known for their use in cosmetics, food industries, and traditional
medicine. This study presents the chemical composition and therapeutic properties against …

Discovery of highly potent proapoptotic antiestrogens in a series of androst-5, 16-dienes D-modified with imidazole-annulated pendants

V Birukova, A Scherbakov, A Ilina, D Salnikova… - The Journal of Steroid …, 2023 - Elsevier
Heterocyclic derivatives of steroid hormones are potent anticancer agents, which are used in
the chemotherapy of breast and prostate cancers. Here, we describe a novel series of …

[HTML][HTML] Oxamic acid thiohydrazides and hydrazones based on them as convenient starting compounds for the synthesis of S-and N-containing heterocyclic products …

MM Krayushkin, VN Yarovenko - Arabian Journal of Chemistry, 2024 - Elsevier
The chemistry of hydrazones is currently undergoing intensive development. For example,
thioacylhydrazones, which are synthesized most often from thiosemicarbazides, have …

Difluoroborate complexes in the synthesis of heterocyclic (13α)-estrone derivatives modified at the A-ring

AA Sukhanova, MA Prezent, AN Fakhrutdinov… - Russian Chemical …, 2023 - Springer
An efficient synthesis of (13α)-estrone derivatives containing pyran, isoxazole, or pyrazole
moieties on the A-ring was performed based on difluoroborate complexes using the chelate …

Secosteroidal hydrazides: Promising scaffolds for anti-breast cancer agents

AI Ilovaisky, VM Merkulova, EI Chernoburova… - The Journal of Steroid …, 2021 - Elsevier
A convenient and selective approach to 13, 17-secoestra-1, 3, 5 (10)-trien-17-oic acid
hydrazides and their N'-(het) arylmethylene derivatives was disclosed and these novel types …

Syntheses and medicinal chemistry of spiro heterocyclic steroids

LL Romero-Hernández… - Beilstein Journal of …, 2024 - beilstein-journals.org
There is compelling evidence that incorporating a heterocyclic moiety into a steroid can alter
its pharmacological and pharmacokinetic properties, driving intense interest in the synthesis …

Pharmacological Assessment of the Carvacrol Chemotype Essential Oil From Plectranthus amboinicus Growing in Cuba

L Monzote, AM Scherbakov, R Scull… - Natural Product …, 2020 - journals.sagepub.com
Plant-derived products are employed in various public health practices and have been
considered as a major source of medicines. The genus Plectranthus (Lamiaceae) has been …

Novel strategy of proxalutamide for the treatment of prostate cancer through coordinated blockade of lipogenesis and androgen receptor axis

Y Gu, M Xue, Q Wang, X Hong, X Wang, F Zhou… - International Journal of …, 2021 - mdpi.com
Objective: Prostate cancer (PCa) is the most common malignant tumor diagnosed in men in
developed countries. In developing countries, the PCa morbidity and mortality rates are also …

In Vitro Pharmacological Screening of Essential Oils from Baccharis parvidentata and Lippia origanoides Growing in Brazil

WH Perera, AM Scherbakov, GI Buravchenko… - Molecules, 2022 - mdpi.com
In this study, the in vitro antimicrobial, antiparasitic, antiproliferative and cytotoxic activities of
essential oil from Baccharis parvidentata Malag.(EO-Bp) and Lippia origanoides Kunth (EO …

New synthetic corticosteroids inhibit Epstein–Barr virus release

AG Malykh, AR Pavlov, AV Komkov, YA Volkova… - Mendeleev …, 2021 - Elsevier
Abstract Novel spiroandrostene-17, 6'-[1, 3, 4] thiadiazines obtained by synthesis from 16β,
17β-epoxy-17-isopregn-5-en-3β-ol-20-one and N-aryl-2-hydrazino-2-thioxoacetamide …