Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …

The heart is the first organ formed during mammalian development. A properly sized and
functional heart is vital throughout the entire lifespan. Loss of cardiomyocytes because of …

The balance between stem cell potency and lineage specification entails the integration of
both extrinsic and intrinsic cues, which ultimately influence gene expression through the …

Epigenetic alterations are a hallmark of aging and age‐related diseases. Computational
models using DNA methylation data can create “epigenetic clocks” which are proposed to …

Mutations in the LMNA gene encoding Lamin A and C (Lamin A/C), major components of the
nuclear lamina, cause laminopathies including dilated cardiomyopathy (DCM), but the …

Heart disease continues to be the leading cause of morbidity and mortality worldwide.
Cardiac malformation during development could lead to embryonic or postnatal death …

Cardiovascular disease (CVD) remains the leading cause of death globally, and heart
failure is a major component of CVD-related morbidity and mortality. The development of …

The Hippo-TEAD pathway regulates cellular proliferation and function. The existing
paradigm is that TEAD co-activators, YAP and TAZ, and co-repressor, VGLL4, bind to the …

The Hippo pathway is an evolutionarily and functionally conserved signalling pathway that
controls organ size by regulating cell proliferation, apoptosis, and differentiation. Emerging …

Resveratrol is a natural phytophenol that exhibits cardioprotective effects. This study was
designed to elucidate the mechanisms by which resveratrol protects against diabetes …