Down syndrome fits an immunophenotype of combined immunodeficiency with
immunodysregulation, manifesting with increased susceptibility to infections, autoimmunity …

Multiple sclerosis, a condition characterised by demyelination and axonal damage in the
central nervous system, is due to autoreactive immune cells that recognise myelin antigens …

Lysine crotonylation modification is a novel acylation modification that is similar to
acetylation modification. Studies have found that protein acetylation plays an important …

Background and Objectives To investigate the total circular RNA (circRNA) profile in patients
with relapsing-remitting multiple sclerosis (RRMS) and healthy controls (HCs). Methods …

Abstract Chromosomal translocation (4; 14), an adverse prognostic factor in multiple
myeloma (MM), drives overexpression of the histone methyltransferase nuclear receptor …

Primary immune deficiency (PID) disorders are clinically and molecularly heterogeneous
diseases. T cell receptor excision circles (TRECs) and κ (kappa)-deleting excision circles …

Recent advances in the field of inborn errors of immunity (IEIs) have been wide in scope,
including progress in mechanisms of disease, diagnosis, and management. New gene …

The surrounding non-cancer cells and tumor cells that make up the tumor microenvironment
(TME) have various metabolic rhythms. TME metabolic heterogeneity is influenced by the …

Human coilin‐interacting nuclear ATPase protein (hCINAP), also known as adenylate
kinase 6 (AK6), is an atypical adenylate kinase with critical roles in many biological …

Background Adenylate kinase (AK) is a monomolecular enzyme widely found in a variety of
organisms. It mainly catalyses the reversible transfer of adenosine nucleotide phosphate …