Cytosolic Ca 2+ concentration levels fluctuate in an ordered manner along the cell cycle, in
line with the fact that Ca 2+ is involved in the regulation of cell proliferation. Cell proliferation …

The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present
in all types of nerve cells. The ER is an interconnected, internally continuous system of …

Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are morpho-functional
units, formed at the loci of close apposition of the ER-forming endomembrane and outer …

Evidence accumulated over more than two decades has implicated Ca2+ dysregulation in
brain aging and Alzheimer's disease (AD), giving rise to the Ca2+ hypothesis of brain aging …

Activation of calcium-ion (Ca 2+) channels on the plasma membrane and on intracellular Ca
2+ stores, such as the endoplasmic reticulum, generates local transient increases in the …

In the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS), motor neurons
degenerate with signs of organelle fragmentation, free radical damage, mitochondrial Ca2+ …

Astroglia possess excitability based on movements of Ca2+ ions between intracellular
compartments and plasmalemmal Ca2+ fluxes. This “Ca2+ excitability” is controlled by …

At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca2+
concentration ([Ca2+] c) depends on at least four efficient regulatory systems: 1) …

ERp57 is a lumenal protein of the endoplasmic reticulum (ER) and a member of the protein
disulfide isomerase (PDI) family. In contrast to archetypal PDI, ERp57 interacts specifically …

Specific Ca2+ homeostatic system appeared very early in the history of the cell, as a survival
system preventing Ca2+-mediated cell damage. This homeostatic system produced a steep …