Advanced techniques for detecting protein misfolding and aggregation in cellular environments

Y Bai, S Zhang, H Dong, Y Liu, C Liu… - Chemical Reviews, 2023 - ACS Publications
Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Multipronged diagnostic and therapeutic strategies for Alzheimer's disease

M Ramesh, T Govindaraju - Chemical science, 2022 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …

Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease

Y Liu, D Zhuang, J Wang, H Huang, R Li, C Wu… - Analyst, 2022 - pubs.rsc.org
Nowadays, it is still quite challenging to achieve an early diagnosis of the Alzheimer disease
(AD) in clinics. The burgeoning near-infrared fluorescence (NIRF) imaging fulfills the …

Research progress of multi-functional fluorescent probes for Alzheimer's disease monitoring

J Yang, Y Guo, M Pistolozzi, J Yan - Dyes and Pigments, 2021 - Elsevier
The diagnosis of Alzheimer's disease (AD) has proven to be difficult to achieve in clinical
practice, despite the extensive research on the subject. In addition to traditional biomarkers …

Rational design of quinoxalinone-based red-emitting probes for high-affinity and long-term visualizing amyloid-β in vivo

XY Liu, XJ Wang, L Shi, YH Liu, L Wang, K Li… - Analytical …, 2022 - ACS Publications
Alzheimer's disease (AD) is a progressive neurodegenerative disease with insidious onset,
and the deposition of amyloid-β (Aβ) is believed to be one of the main cause. Fluorescence …

Small molecular fluorescent probes for Alzheimer's disease associated active species

F Tang, K Wang, X Liu, X Zhang, W Zhou… - … A European Journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the main
cause of dementia worldwide. As the pathogenesis of AD is quite complicated, there is …

Advances in targeted tracking and detection of soluble amyloid-β aggregates as a biomarker of Alzheimer's disease

H Gao, J Chen, Y Huang, R Zhao - Talanta, 2024 - Elsevier
Misfolding and aggregation of amyloid-β (Aβ) peptides are key hallmarks of Alzheimer's
disease (AD). With accumulating evidence suggesting that different Aβ species have varied …

Cost-effective simulations of vibrationally-resolved absorption spectra of fluorophores with machine-learning-based inhomogeneous broadening

EF Petrusevich, MHE Bousquet… - Journal of Chemical …, 2023 - ACS Publications
The results of electronic and vibrational structure simulations are an invaluable support for
interpreting experimental absorption/emission spectra, which stimulates the development of …

Evaluation of N, O-Benzamide difluoroboron derivatives as near-infrared fluorescent probes to detect β-amyloid and tau tangles

Y Chen, Q Ouyang, Y Li, Q Zeng, B Dai, Y Liang… - European Journal of …, 2022 - Elsevier
Abstract β-Amyloid (Aβ) plaques and Tau tangles are cognitive impairment markers vital for
diagnosing and preventing Alzheimer's disease (AD). To systematically explore the …

BF2-Functionalized Benzothiazole Amyloid Markers: Effect of Donor Substituents on One- and Two-Photon Properties

A Hajda, M Grelich-Mucha, P Rybczyński… - ACS Applied Bio …, 2023 - ACS Publications
Investigation of amyloids with the aid of fluorescence microscopy provides crucial insights
into the development of numerous diseases associated with the formation of aggregates …