Role of ADAM and ADAMTS disintegrin and metalloproteinases in normal pregnancy and preeclampsia

H Qu, RA Khalil - Biochemical Pharmacology, 2022 - Elsevier
Normal pregnancy (NP) involves intricate processes starting with egg fertilization,
proceeding to embryo implantation, placentation and gestation, and culminating in …

The involvement of cell adhesion molecules, tight junctions, and gap junctions in human placentation

EA Adu-Gyamfi, A Czika, PN Gorleku, A Ullah… - Reproductive …, 2021 - Springer
Placentation is a major determinant of the success of pregnancy. It is regulated by several
factors such as cell adhesion molecules, tight junctions, and gap junctions. The cell …

Activin A increases human trophoblast invasion by upregulating integrin β1 through ALK4

S Zhu, Z Li, L Cui, Y Ban, PCK Leung, Y Li… - The FASEB …, 2021 - Wiley Online Library
Activin A promotes human trophoblast invasion during the first trimester of pregnancy and is
associated with preeclampsia and pregnancy‐induced hypertension (PE/PIH) in naturally …

[HTML][HTML] ADAM8 deficiency in macrophages promotes cardiac repair after myocardial infarction via ANXA2-mTOR-autophagy pathway

Z Ji, J Guo, R Zhang, W Zuo, Y Xu, Y Qu, Z Tao… - Journal of Advanced …, 2024 - Elsevier
Introduction A disintegrin and metalloproteinase 8 (ADAM8), a crucial regulator in
macrophages, is closely associated with cardiovascular disease progression. Objectives …

Mitochondrial dynamics in placenta-derived mesenchymal stem cells regulate the invasion activity of trophoblast

J Seok, S Jun, JO Lee, GJ Kim - International Journal of Molecular …, 2020 - mdpi.com
Mitochondrial dynamics are involved in many cellular events, including the proliferation,
differentiation, and invasion/migration of normal as well as cancerous cells. Human placenta …

ADAM and ADAMTS disintegrin and metalloproteinases as major factors and molecular targets in vascular malfunction and disease

HF Yang, RA Khalil - Advances in Pharmacology, 2022 - Elsevier
Abstract A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and
Metalloproteinase with Thrombospondin Motifs (ADAMTS) are two closely related families of …

ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis

K Chen, H Tao, P Zhu, M Chu, X Li, Y Shi… - Arthritis Research & …, 2024 - Springer
Objective Osteoarthritis (OA) is a degenerative joint disease that affects elderly populations
worldwide, causing pain and disability. Alteration of the fibroblast-like synoviocytes (FLSs) …

RETRACTED: Palmitic Acid Impedes Extravillous Trophoblast Activity by Increasing MRP1 Expression and Function

Y Ashar, Q Teng, JND Wurpel, ZS Chen, SE Reznik - Biomolecules, 2022 - mdpi.com
Normal function of placental extravillous trophoblasts (EVTs), which are responsible for
uteroplacental vascular remodeling, is critical for adequate delivery of oxygen and nutrients …

An Extracellular/Membrane-Bound S100P Pool Regulates Motility and Invasion of Human Extravillous Trophoblast Lines and Primary Cells

T Lancaster, MEA Tabrizi, M Repici, J Gupta, SR Gross - Biomolecules, 2023 - mdpi.com
Whilst S100P has been shown to be a marker for carcinogenesis, we have shown, in non-
physio-pathological states, that its expression promotes trophoblast motility and invasion but …

Downregulation of lncRNA IGF2-AS-encoded peptide induces trophoblast–cycle arrest

AH Wu, XL Chen, LY Guo, DF Lu, S Lu… - Reproductive …, 2021 - Elsevier
Abstract Research question lncRNA IGF2-AS may be related to early pregnancy loss. Does
lncRNA IGF2-AS affect trophoblast cell growth? The aim of the present study was to verify …