The tremendous therapeutic potential of voltage-gated sodium channels (Navs) has been
the subject of many studies in the past and is of intense interest today. Nav1. 7 channels in …

A variety of ion channels have been detected in cancer cells. In particular, upregulation of
voltage-gated sodium channels (VGSCs) has been associated pathophysiologically with …

Disulfide-rich peptides are the dominant component of most animal venoms. These peptides
have received much attention as leads for the development of novel therapeutic agents and …

Loss-of-function mutations of NaV1. 7 lead to congenital insensitivity to pain, a rare condition
resulting in individuals who are otherwise normal except for the inability to sense pain …

The voltage-gated sodium channel Nav1. 7 plays a crucial role in pain, and drugs that inhibit
hNav1. 7 may have tremendous therapeutic potential. ProTx-II and huwentoxin-IV (HWTX …

The sodium channel Nav1. 7 is crucial for impulse generation and conduction in peripheral
pain pathways [1]. In Neanderthals, the Nav1. 7 protein carried three amino acid …

Painful venoms are used to deter predators. Pain itself, however, can signal damage and
thus serves an important adaptive function. Evolution to reduce general pain responses …

Spider venoms are a rich source of ion channel modulators with therapeutic potential. Given
the analgesic potential of subtype-selective inhibitors of voltage-gated sodium (NaV) …

Toxins and venom components that target voltage-gated sodium (Na V) channels have
evolved numerous times due to the importance of this class of ion channels in the normal …

The ability to sense temperature is crucial for the survival of an organism. Temperature
influences all biological operations, from rates of metabolic reactions to protein folding, and …