Microvascular complications in diabetes: A growing concern for cardiologists

A Avogaro, GP Fadini - International journal of cardiology, 2019 - Elsevier
Randomized, cross-sectional, and prospective studies have demonstrated that
microvascular complications in patients with diabetes are not only the cause of blindness …

Diabetes and arrhythmias: pathophysiology, mechanisms and therapeutic outcomes

LA Grisanti - Frontiers in physiology, 2018 - frontiersin.org
The prevalence of diabetes is rapidly increasing and closely associated with cardiovascular
morbidity and mortality. While the major cardiovascular complication associated with …

Type 2 diabetes mellitus and higher rate of complete atrioventricular block: a Danish Nationwide Registry

S Haxha, A Halili, M Malmborg… - European Heart …, 2023 - academic.oup.com
Aims The present study aimed to determine the association between Type 2 diabetes
mellitus (T2DM) and third-degree (complete) atrioventricular block. Methods and results This …

Long term high fat diet treatment: an appropriate approach to study the sex-specificity of the autonomic and cardiovascular responses to obesity in mice

T Bruder-Nascimento, OJ Ekeledo, R Anderson… - Frontiers in …, 2017 - frontiersin.org
Obesity-related cardiovascular disease (CVD) involves increased sympathetic activity in
men and male animals. Although women exhibit increased visceral fat, metabolic disorders …

Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction

ITN Nguyen, MM Brandt, J van De Wouw… - PLoS …, 2020 - journals.plos.org
Heart failure with a preserved ejection fraction (HFpEF) is associated with multiple
comorbidities, such as old age, hypertension, type 2 diabetes and obesity and is more …

Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats

LJ Daniels, RS Wallace, OM Nicholson… - Cardiovascular …, 2018 - Springer
Background Calcium/calmodulin-dependent kinase II-delta (CaMKIIδ) activity is enhanced
during hyperglycemia and has been shown to alter intracellular calcium handling in …

O-GlcNAcylation is crucial for sympathetic neuron development, maintenance, functionality and contributes to peripheral neuropathy

HF Wu, CW Huang, J Art, HX Liu, GW Hart… - Frontiers in …, 2023 - frontiersin.org
O-GlcNAcylation is a post-translational modification (PTM) that regulates a wide range of
cellular functions and has been associated with multiple metabolic diseases in various …

Mechanisms and pharmacotherapy of hypertension associated with type 2 diabetes

V Kamalumpundi, E Shams, C Tucker, L Cheng… - Biochemical …, 2022 - Elsevier
Type 2 diabetes is often complicated with hypertension, such that 73.6% of patients≥ 18
years with type 2 diabetes also have hypertension. With increasing age, the risk of …

Sirt1 and Sirt3 activation improved cardiac function of diabetic rats via modulation of mitochondrial function

B Paramesha, MS Anwar, H Meghwani, SK Maulik… - Antioxidants, 2021 - mdpi.com
In the present study, we aimed to evaluate the effect of Sirt1, Sirt3 and combined activation
in high fructose diet-induced insulin resistance rat heart and assessed the cardiac function …

Strong independent association between third-degree AV-block and diabetes mellitus using a large database

MR Movahed, A Bahrami, C Manrique… - Diabetes Research and …, 2023 - Elsevier
Background Recent data suggests an association between DM and third-degree AV-Block.
The goal of this study was to evaluate the independent association between diabetes and …