Atherosclerosis underlies most cardiovascular diseases, and is accepted as a primary cause
of mortality worldwide. Proteases have been implicated in the development and progression …

The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family
comprises 19 proteases that regulate the structure and function of extracellular proteins in …

Proteolytic cleavage represents a unique and irreversible posttranslational event regulating
the function and half-life of many intracellular and extracellular proteins. The …

The epidermal growth factor receptor (EGFR) family and its ligands serve as a switchboard
for the regulation of multiple cellular processes. While it is clear that EGFR activity is …

Abstract A Disintegrin and Metalloproteinase (ADAM) is a family of proteolytic enzymes that
possess sheddase function and regulate shedding of membrane-bound proteins, growth …

The extracellular matrix (ECM) is an essential component of the human body that is
responsible for the proper function of various organs. Changes in the ECM have been …

A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitously expressed transmembrane
metalloprotease that cleaves the extracellular regions from its transmembrane substrates …

The 'A Disintegrin And Metalloproteinase 10'(ADAM10) has gained considerable attention
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …

One of the shared hallmarks of neurodegenerative diseases is the accumulation of
misfolded proteins. Therefore, it is suspected that normal proteostasis is crucial for neuronal …

The extracellular matrix is comprised of 1100 core-matrisome and matrisome-associated
proteins and of glycosaminoglycans. This structural scaffold contributes to the organization …