Resistance to chemotherapy and molecularly targeted therapies is a major problem facing
current cancer research. The mechanisms of resistance to'classical'cytotoxic …

Colorectal cancer (CRC) persists as one of the most prevalent and deadly tumor types in
both men and women worldwide. This is in spite of widespread, effective measures of …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Over the past 60 years, chemotherapeutic agents that target thymidylate biosynthesis and
the enzyme thymidylate synthase (TS) have remained among the most-successful drugs …

Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years,
increased understanding of the mechanism of action of 5-FU has led to the development of …

Gastric cancer is the second most frequent cause of cancer death worldwide, although much
geographical variation in incidence exists. Prevention and personalised treatment are …

Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …

The purpose of this work is to review the published studies on the mechanisms of action and
resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of …

Although effective drugs have been developed, including 5-fluorouracil (5-FU), advanced
colorectal cancer (CRC) shows low therapeutic sensitivity resulting from the development of …

BACKGROUND To the authors' knowledge, the significance of postoperative adjuvant
chemotherapy in pancreaticobiliary carcinoma has not yet been clarified. A randomized …