Since determination of the myoglobin structure in 1957, X-ray crystallography, as the
anchoring tool of structural biology, has played an instrumental role in deciphering the …

Specific interactions between proteins and DNA are fundamental to many biological
processes. In this review, we provide a revised view of protein-DNA interactions that …

One of the most important regulatory small molecules in plants is indole-3-acetic acid, also
known as auxin. Its dynamic redistribution has an essential role in almost every aspect of …

The recognition of specific DNA sequences by proteins is thought to depend on two types of
mechanism: one that involves the formation of hydrogen bonds with specific bases, primarily …

Intrinsic disorder refers to segments or to whole proteins that fail to self‐fold into fixed 3D
structure, with such disorder sometimes existing in the native state. Here we report data on …

The zinc finger DNA-binding motif occurs in many proteins that regulate eukaryotic gene
expression. The crystal structure of a complex containing the three zinc fingers from Zif268 …

During recent decades it has become feasible to simulate the dynamics of molecular
systems on a computer. The method of molecular dynamics (MD) solves Newton's equations …

The x-ray crystal structure of the complex between human growth hormone (hGH) and the
extracellular domain of its first bound receptor (hGHbp) shows that about 30 side chains …

Solvent binding in the nucleosome core particle containing a 147 base pair, defined-
sequence DNA is characterized from the X-ray crystal structure at 1.9 Å resolution. A single …

The three-dimensional structure of an HNF-3/fork head DNA-recognition motif complexed
with DNA has been determined by X-ray crystallography at 2.5 Å resolution. This α/β protein …