Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …

The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …

Here, we provide fundamental insights into early human development by single-cell RNA-
sequencing of human and mouse preimplantation embryos. We elucidate conserved …

Germ cell development creates totipotency through genetic as well as epigenetic regulation
of the genome function. Primordial germ cells (PGCs) are the first germ cell population …

The embryo instructs the allocation of cell states to spatially regulate functions. In the
blastocyst, patterning of trophoblast (TR) cells ensures successful implantation and …

Naive and primed pluripotent human embryonic stem cells bear transcriptional similarity to
pre-and post-implantation epiblast and thus constitute a developmental model for …

Placentation is a reproductive adaptation that permits fetal growth and development within
the protected confines of the female reproductive tract. Through this important role, the …

The AP-2 family of transcription factors consists of five different proteins in humans and mice:
AP-2α, AP-2β, AP-2γ, AP-2δ and AP-2ε. Frogs and fish have known orthologs of some but …

Trophoblast giant cells (TGCs) are the first cell type to terminally differentiate during
embryogenesis and are of vital importance for implantation and modulation of post …

To elucidate the molecular basis of BMP4-induced differentiation of human pluripotent stem
cells (PSCs) toward progeny with trophectoderm characteristics, we produced transcriptome …