During reactivation from latency, gammaherpesviruses radically restructure their host cell to
produce virion particles. To achieve this and thwart cellular defenses, they induce rapid …

Lymphoblastoid cell lines (LCLs) are generated by transforming primary B cells with Epstein–
Barr virus (EBV) and are used extensively as model systems in viral oncology, immunology …

The timing of transcription and replication must be carefully regulated for heavily-transcribed
genomes of double-stranded DNA viruses: transcription of immediate early/early genes must …

Herpesviruses establish latency to ensure permanent residence in their hosts. Upon entry
into a cell, these viruses are rapidly silenced by the host, thereby limiting the destructive viral …

The success of long-term host–virus partnerships is predicated on the ability of the host to
limit the destructive potential of the virus and the virus's skill in manipulating its host to …

ABSTRACT The ability of Epstein-Barr virus (EBV) to switch between latent and lytic
infection is key to its long-term persistence, yet the molecular mechanisms behind this switch …

There are nine herpesviruses known to infect humans, of which Epstein–Barr virus (EBV) is
the most widely distributed (> 90% of adults infected). This ubiquitous virus is implicated in a …

The herpes virus genome bears more than 80 strong transcriptional promoters. Upon entry
into the host cell nucleus, these genes are transcribed in an orderly manner, producing five …

Human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated
herpesvirus (KSHV) persist as life-long infections alternating between latency and lytic …

Epstein-Barr virus (EBV) is one of nine human herpesviruses that persist latently to establish
permanent residence in their hosts. Periodic activation into the lytic/replicative phase allows …