Drug delivery through the skin offers many advantages such as avoidance of hepatic first-
pass metabolism, maintenance of steady plasma concentration, safety, and compliance over …

Transdermal drug delivery systems have been around for decades, and current
technologies (eg, patches, ointments, and creams) enhance the skin permeation of low …

Vesicular drug delivery systems have gained wide attention in the field of nanotechnology.
Among them proniosomes become the superior over other vesicular carriers. Proniosomes …

Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is
characterized by neuroinflammation, dopaminergic neuronal cell death and motor …

Transdermal drug delivery systems (TDDS) are designed to deliver drugs through the skin
and into the systemic circulation. They offer several advantages over traditional oral or …

Treatment of cancer pain is generally based on the three-step World Health Organization
(WHO) pain relief ladder, which utilizes a sequential approach with drugs of increasing …

Poor solubility and appreciable first-pass metabolism have limited the oral bioavailability of
nebivolol. The objective of the current investigation was to design, formulate, and optimize a …

Introduction Despite their effectiveness and indispensability, many drugs are poorly solvated
in aqueous solutions. Over recent decades, the need for targeted drug delivery has led to …

Mefenamic acid (MA) is a BCS II class NSAID drug. It is available only in the form of tablets,
capsules, and pediatric suspensions. Oral administration of MA is associated with severe …

Materials and Methods Sixty patients undergoing major abdominal surgery under GA were
randomly divided in two groups (n= 30). Group A received buprenorphine 10 mcg/h TDS …