Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

The wingless-related integration site (Wnt) signaling pathway plays an essential role in
embryonic development and nervous system regulation. It is critically involved in multiple …

Background Inflammation often leads to the occurrence of chronic pain, and many miRNAs
have been shown to play a key role in the development of inflammatory pain. However …

Chronic pain is a debilitating condition that influences the social, economic, and
psychological aspects of patients' lives. Hence, the need for better treatment is drawing …

Chronic pain is a prevalent neurological complication among individuals living with human
immunodeficiency virus (PLHIV) in the post-combination antiretroviral therapy (cART) era …

In males but not in females, brain derived neurotrophic factor (BDNF) plays an obligatory
role in the onset and maintenance of neuropathic pain. Afferent terminals of injured …

Wnt signaling represents a highly versatile signaling system, which plays critical roles in
developmental morphogenesis as well as synaptic physiology in adult life and is implicated …

Despite the rapid advance over the past decades to design effective therapeutic
pharmacological interventions, chronic pain remains to be an unresolved healthcare …

Brain-derived neurotrophic factor (BDNF) is a master regulator of synaptic plasticity in
various neural circuits of the mammalian central nervous system. Neuron activity–induced …

Introduction: Current pharmacotherapeutics for neuropathic pain offer only symptomatic
relief without treating the underlying pathophysiology. Additionally, they are associated with …