Hypoxia is an integral component of the tumor microenvironment. Either as chronic or
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …

The consequences of prostate cancer metastasis remain severe, with huge impact on the
mortality and overall quality of life of affected patients. Despite the convoluted interplay and …

Background Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa)
progression and dissemination. Insight in cell-to-cell communication networks provides new …

The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors
(GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They …

Prostate cancer is the second most common malignancy in men and androgen deprivation
therapy is the first‐line therapy. However, most cases will eventually develop castration …

Castration-resistant prostate cancer (CRPC) that has developed resistance to the new-
generation androgen receptor (AR) antagonist enzalutamide is a lethal disease …

The impact of the CXC receptor (CXCR) 7 and its close co-player CXCR4 in different
physiological and pathophysiological processes has been extensively investigated within …

Elevated expression of the chemokine receptors CXCR4 and ACKR3 and of their cognate
ligand CXCL12 is detected in a wide range of tumors and the tumor microenvironment …

Although EGFR mutant–selective tyrosine kinase inhibitors (TKI) are clinically effective,
acquired resistance can occur by reactivating ERK. We show using in vitro models of …

Multiple mechanisms promote tumor prosperity, which does not only depend on cell-
autonomous, inherent abnormal characteristics of the malignant cells that facilitate rapid cell …