Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …

Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex
systems. However, a comprehensive single-cell atlas has not been achieved for humans …

Computational methods that model how gene expression of a cell is influenced by
interacting cells are lacking. We present NicheNet (https://github. com/saeyslab/nichenetr), a …

Cell–cell communication mediated by ligand–receptor complexes is critical to coordinating
diverse biological processes, such as development, differentiation and inflammation. To …

Background Cell-cell interactions are important for information exchange between different
cells, which are the fundamental basis of many biological processes. Recent advances in …

The bone marrow constitutes the primary site for life-long blood production and skeletal
regeneration. However, its cellular and spatial organization remains controversial. Here, we …

Cortical organoids are self-organizing three-dimensional cultures that model features of the
developing human cerebral cortex,. However, the fidelity of organoid models remains …

Distinct T cell infiltration patterns, ie, immune infiltrated, excluded, and desert, result in
different responses to cancer immunotherapies. However, the key determinants and biology …

During early human pregnancy the uterine mucosa transforms into the decidua, into which
the fetal placenta implants and where placental trophoblast cells intermingle and …