Neuritic plaques are pathognomonic and terminal lesions of Alzheimer's Disease (AD). They
embody AD pathogenesis because they harbor in one space critical pathologic features of …

The metformin molecule dates back to over a century, but its clinical use started in the '50 s.
Since then, its use in diabetics has grown constantly, with over 150 million users today. The …

Chronic caloric restriction triggers unfavorable alterations in cardiac function albeit
responsible scenarios remain unclear. This work evaluated the possible involvement of Akt2 …

Population aging and the associated increase in cardiovascular disease rates pose serious
threats to global public health. Different forms of fasting have become an increasingly …

Chaperone-mediated autophagy (CMA) is part of the mammalian cellular proteostasis
network that ensures protein quality control, maintenance of proteome homeostasis, and …

Macroautophagy (autophagy hereafter) is an intracellular nutrient scavenging pathway
induced by starvation and other stressors whereby cellular components such as organelles …

In recent years, there has been a surge in the popularity of fasting as a method to enhance
one's health and overall well-being. Fasting is a customary practice characterized by …

Aim and background A growing body of evidence supports the impact of intermittent fasting
(IF) on longevity and healthy aging via the modulation of autophagy genes. The activation of …

Background Although it is established that caloric restriction offers metabolic and clinical
benefits, the molecular mechanisms underlying these effects remain unclear. Thus, this …

The vasculature system is composed of a multiplicity of juxtaposed cells to generate a
functional biological barrier between the blood and tissues. On the luminal surface of blood …