Cocrystal engineering: a collaborative strategy toward functional materials
Cocrystal engineering with a noncovalent assembly feature by simple constituent units has
inspired great interest and has emerged as an efficient and versatile route to construct …
inspired great interest and has emerged as an efficient and versatile route to construct …
Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals
Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …
Polymorphism in cocrystals: a review and assessment of its significance
Cocrystals have gained much interest in recent years owing to their potential to improve the
physicochemical properties of the parent compounds. It was once thought that cocrystals …
physicochemical properties of the parent compounds. It was once thought that cocrystals …
Designing Elastic Organic Crystals: Highly Flexible Polyhalogenated N‐Benzylideneanilines
The intermolecular interactions and structural features in crystals of seven halogenated N‐
benzylideneanilines (Schiff bases), all of which exhibit remarkable flexibility, were examined …
benzylideneanilines (Schiff bases), all of which exhibit remarkable flexibility, were examined …
Co-crystallization and small molecule crystal form diversity: from pharmaceutical to materials applications
S Cherukuvada, R Kaur, TNG Row - CrystEngComm, 2016 - pubs.rsc.org
Co-crystallization is the supramolecular phenomenon of aggregation of two or more different
chemical entities in a crystalline lattice through non-covalent interactions. It encompasses …
chemical entities in a crystalline lattice through non-covalent interactions. It encompasses …
Twistable pharmaceutical crystal exhibiting exceptional plasticity and tabletability
We report here the first pharmaceutical twistable hydrogen-bonded two-dimensional plastic
hydrate crystal of a well-known psychoactive drug, caffeine (CAH). The availability of two …
hydrate crystal of a well-known psychoactive drug, caffeine (CAH). The availability of two …
Photosalience and Thermal Phase Transitions of Azobenzene-and Crown Ether-Based Complexes in Polymorphic Crystals
Stimuli-responsive molecular crystals have attracted considerable attention as promising
smart materials with applications in various fields such as sensing, actuation, and …
smart materials with applications in various fields such as sensing, actuation, and …
Multicomponent flexible organic crystals
X Ding, C Wei, L Wang, J Yang, W Huang, Y Chang… - …, 2024 - Wiley Online Library
Flexible organic crystals are emerging as a potential candidate for smart materials and have
aroused great interest over the past decade. In view of multicomponent supramolecular …
aroused great interest over the past decade. In view of multicomponent supramolecular …
Challenges in translational development of pharmaceutical cocrystals
The last 2 decades have witnessed increased research in the area of cocrystals resulting in
deeper scientific understanding, increase in intellectual property landscape, and evolution in …
deeper scientific understanding, increase in intellectual property landscape, and evolution in …
Tuning mechanical properties of pharmaceutical crystals with multicomponent crystals: voriconazole as a case study
Crystals of voriconazole, an antifungal drug, are soft in nature, and this is disadvantageous
during compaction studies where pressure is applied on the solid. Crystal engineering is …
during compaction studies where pressure is applied on the solid. Crystal engineering is …