Cocrystal engineering: a collaborative strategy toward functional materials

L Sun, Y Wang, F Yang, X Zhang, W Hu - Advanced Materials, 2019 - Wiley Online Library
Cocrystal engineering with a noncovalent assembly feature by simple constituent units has
inspired great interest and has emerged as an efficient and versatile route to construct …

Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals

AM Healy, ZA Worku, D Kumar, AM Madi - Advanced drug delivery reviews, 2017 - Elsevier
Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …

Polymorphism in cocrystals: a review and assessment of its significance

S Aitipamula, PS Chow, RBH Tan - CrystEngComm, 2014 - pubs.rsc.org
Cocrystals have gained much interest in recent years owing to their potential to improve the
physicochemical properties of the parent compounds. It was once thought that cocrystals …

Designing Elastic Organic Crystals: Highly Flexible Polyhalogenated N‐Benzylideneanilines

S Ghosh, MK Mishra, SB Kadambi… - Angewandte Chemie …, 2015 - Wiley Online Library
The intermolecular interactions and structural features in crystals of seven halogenated N‐
benzylideneanilines (Schiff bases), all of which exhibit remarkable flexibility, were examined …

Co-crystallization and small molecule crystal form diversity: from pharmaceutical to materials applications

S Cherukuvada, R Kaur, TNG Row - CrystEngComm, 2016 - pubs.rsc.org
Co-crystallization is the supramolecular phenomenon of aggregation of two or more different
chemical entities in a crystalline lattice through non-covalent interactions. It encompasses …

Twistable pharmaceutical crystal exhibiting exceptional plasticity and tabletability

S Hu, MK Mishra, CC Sun - Chemistry of Materials, 2019 - ACS Publications
We report here the first pharmaceutical twistable hydrogen-bonded two-dimensional plastic
hydrate crystal of a well-known psychoactive drug, caffeine (CAH). The availability of two …

Photosalience and Thermal Phase Transitions of Azobenzene-and Crown Ether-Based Complexes in Polymorphic Crystals

CH Wang, YC Lin, S Bhunia, Y Feng… - Journal of the …, 2023 - ACS Publications
Stimuli-responsive molecular crystals have attracted considerable attention as promising
smart materials with applications in various fields such as sensing, actuation, and …

Multicomponent flexible organic crystals

X Ding, C Wei, L Wang, J Yang, W Huang, Y Chang… - …, 2024 - Wiley Online Library
Flexible organic crystals are emerging as a potential candidate for smart materials and have
aroused great interest over the past decade. In view of multicomponent supramolecular …

Challenges in translational development of pharmaceutical cocrystals

DP Kale, SS Zode, AK Bansal - Journal of pharmaceutical sciences, 2017 - Elsevier
The last 2 decades have witnessed increased research in the area of cocrystals resulting in
deeper scientific understanding, increase in intellectual property landscape, and evolution in …

Tuning mechanical properties of pharmaceutical crystals with multicomponent crystals: voriconazole as a case study

P Sanphui, MK Mishra, U Ramamurty… - Molecular …, 2015 - ACS Publications
Crystals of voriconazole, an antifungal drug, are soft in nature, and this is disadvantageous
during compaction studies where pressure is applied on the solid. Crystal engineering is …