Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

Fibroblasts are cells present throughout the human body that are primarily responsible for
the production and maintenance of the extracellular matrix (ECM) within the tissues. They …

Cells exert, sense, and respond to physical forces through an astounding diversity of
mechanisms. Here we review recently developed tools to quantify the forces generated by …

Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

Intestinal organoids capture essential features of the intestinal epithelium such as crypt
folding, cellular compartmentalization and collective movements. Each of these processes …

The linkage of cells to their microenvironment is mediated by a series of bonds that
dynamically engage and disengage, in what has been conceptualized as the molecular …

Mechanotransduction is a process by which cells sense the mechanical properties of their
surrounding environment and adapt accordingly to perform cellular functions such as …