Validation of in-vitro bioassay methods: Application in herbal drug research

G Indrayanto, GS Putra, F Suhud - Profiles of drug substances, excipients …, 2021 - Elsevier
This present review described the validation method of in-vitro bioassay for its application in
herbal drug research. Seven sequencing steps that can be taken for performing a valid …

In vitro cytotoxicity and cell viability assays: principles, advantages, and disadvantages

ÖS Aslantürk - Genotoxicity-A predictable risk to our actual world, 2018 - books.google.com
Cytotoxicity is one of the most important indicators for biological evaluation in vitro studies. In
vitro, chemicals such as drugs and pesticides have different cytotoxicity mechanisms such …

[HTML][HTML] Screening for molecular glues–challenges and opportunities

GA Holdgate, C Bardelle, SK Berry, A Lanne… - SLAS Discovery, 2024 - Elsevier
Molecular glues are small molecules, typically smaller than PROTACs, and usually with
improved physicochemical properties that aim to stabilise the interaction between two …

Nanofat cell aggregates: a nearly constitutive stromal cell inoculum for regenerative site-specific therapies

B Sesé, JM Sanmartín, B Ortega… - Plastic and …, 2019 - journals.lww.com
Background: Recent technology developed by Tulip Medical Products allows clinicians to
mechanically disaggregate fat tissue into small fat particles known as nanofat. The present …

Streptomyces sp SM01 isolated from Indian soil produces a novel antibiotic picolinamycin effective against multi drug resistant bacterial strains

PK Maiti, S Das, P Sahoo, S Mandal - Scientific reports, 2020 - nature.com
Abstract A Kashmir Himalayan (India) soil isolate, Streptomyces sp. SM01 was subjected to
small scale fermentation for the production of novel antimicrobials, picolinamycin (SM1). The …

Functionalized graphene oxide coating on Ti6Al4V alloy for improved biocompatibility and corrosion resistance

H Asgar, KM Deen, ZU Rahman, UH Shah… - Materials Science and …, 2019 - Elsevier
The present study focused on the development of magnesium-functionalized graphene
oxide (FGO) coating on titanium alloy (Ti6Al4V) by electrophoretic deposition. Graphene …

Neuroprotective role for RORA in Parkinson's disease revealed by analysis of post-mortem brain and a dopaminergic cell line

FS Al-Zaid, MJ Hurley, DT Dexter, GE Gillies - npj Parkinson's Disease, 2023 - nature.com
Parkinson's disease (PD) is almost twice as prevalent in men, which has largely been
attributed to neuroprotective effect of oestradiol in women. RORA (retinoic acid receptor …

Electronic cigarette refill fluids sold worldwide: flavor chemical composition, toxicity, and hazard analysis

EE Omaiye, W Luo, KJ McWhirter… - Chemical research in …, 2020 - ACS Publications
Flavor chemicals in electronic cigarette (EC) fluids, which may negatively impact human
health, have been studied in a limited number of countries/locations. To gain an …

Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C–H Dibenzothiophenation and Negishi Coupling

C Yang, LP Slavetinska, M Fleuti… - Journal of the …, 2022 - ACS Publications
A new approach for synthesizing polycyclic heterofused 7-deazapurine heterocycles and the
corresponding nucleosides was developed based on C–H functionalization of diverse …

Enhancing Ocular Drug Delivery: The Effect of Physicochemical Properties of Nanoparticles on the Mechanism of Their Uptake by Human Cornea Epithelial Cells

M Azadi, AE David - ACS Biomaterials Science & Engineering, 2023 - ACS Publications
This study investigates the effect of nanoparticle size and surface chemistry on interactions
of the nanoparticles with human cornea epithelial cells (HCECs). Poly (lactic-co-glycolic) …