Genome data have revealed great variation in the numbers of genes in different organisms,
which indicates that there is a fundamental process of genome evolution: the origin of new …

Differences between males and females in the optimal phenotype that is favoured by
selection can be resolved by the evolution of differential gene expression in the two sexes …

Sexual reproduction is a fundamental aspect of life. It is defined by the occurrence of meiosis
and the fusion of two gametes of different sexes or mating types. Sex-determination …

A principal challenge currently facing biologists is how to connect the complete DNA
sequence of an organism to its development and behaviour. Large-scale targeted-deletions …

To elucidate gene function on a global scale, we identified pairs of genes that are
coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found …

The emergence of large gene expression datasets has revealed the need for improved tools
to identify enriched gene categories and visualize enrichment patterns. While gene …

The increased longevity of the C. elegans electron transport chain mutants isp-1 and nuo-6
is mediated by mitochondrial ROS (mtROS) signaling. Here we show that the mtROS signal …

To initiate studies on how protein-protein interaction (or “interactome”) networks relate to
multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans …

Glutathione (GSH) is the most abundant cellular antioxidant. As reactive oxygen species
(ROS) are widely believed to promote aging and age-related diseases, and antioxidants can …

Histone methylation regulates chromatin structure, transcription, and epigenetic state of the
cell. Histone methylation is dynamically regulated by histone methylases and demethylases …