Extracellular vesicles and particles impact the systemic landscape of cancer

S Lucotti, CM Kenific, H Zhang, D Lyden - The EMBO journal, 2022 - embopress.org
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …

Cancer stem cell functions in hepatocellular carcinoma and comprehensive therapeutic strategies

YC Liu, CT Yeh, KH Lin - Cells, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality owing to
resistance to traditional treatments and tumor recurrence after therapy, which leads to poor …

Cancer-inducing niche: the force of chronic inflammation

SM Afify, G Hassan, A Seno, M Seno - British Journal of Cancer, 2022 - nature.com
The growth of cancer tissue is thought to be considered driven by a small subpopulation of
cells, so-called cancer stem cells (CSCs). CSCs are located at the apex of a hierarchy in a …

Conversion of stem cells to cancer stem cells: undercurrent of cancer initiation

SM Afify, M Seno - Cancers, 2019 - mdpi.com
Cancer stem cells (CSCs) also known as cancer-initiating cells (CIC), are responsible for the
sustained and uncontrolled growth of malignant tumors and are proposed to play significant …

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Cancer stem cells: advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G Xiao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition

SM Tortorella, SG Royce, PV Licciardi… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: Sulforaphane, produced by the hydrolytic conversion of glucoraphanin after
ingestion of cruciferous vegetables, particularly broccoli and broccoli sprouts, has been …

A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment

N Nair, AS Calle, MH Zahra, M Prieto-Vila, AKK Oo… - Scientific reports, 2017 - nature.com
Cancer-associated fibroblasts (CAFs) are one of the most prominent cell types in the stromal
compartment of the tumor microenvironment. CAFs support multiple aspects of cancer …

Cancer extracellular vesicles, tumoroid models, and tumor microenvironment

T Eguchi, M Sheta, M Fujii, SK Calderwood - Seminars in Cancer Biology, 2022 - Elsevier
Cancer extracellular vesicles (EVs), or exosomes, promote tumor progression through
enhancing tumor growth, initiating epithelial-to-mesenchymal transition, remodeling the …

A novel model of liver cancer stem cells developed from induced pluripotent stem cells

SM Afify, A Sanchez Calle, G Hassan, K Kumon… - British Journal of …, 2020 - nature.com
Background Liver cancer is the second most common cause of cancer-related death. Every
type of tumours including liver cancer contains cancer stem cells (CSCs). To date, the …