Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

The body's response to tissue injury in a healthy individual is an intricate, sequential
physiologic process that results in timely healing with full re-epithelialization, resolution of …

Chronic wounds, such as venous ulcers, are characterized by physiological impairments
manifested by delays in healing, resulting in severe morbidity. Surgical debridement is …

The evidence base underpinning most traditional scar reduction approaches is limited, but
some of the novel strategies are promising and accumulating. We review a number of …

Glucocorticoids (GCs) are steroidal ligands for the GC receptor (GR), which can function as
a ligand-activated transcription factor. These steroidal ligands and derivatives thereof are …

Over 100 million patients acquire scars in the industrialized world each year, primarily as a
result of elective operations. Although undefined, the global incidence of scarring is even …

First described for their metabolic and immunosuppressive effects, glucocorticoids are
widely prescribed in clinical settings of inflammation. However, glucocorticoids are also …

There is a broad consensus that glucocorticoids (GCs) exert anti-inflammatory effects largely
by inhibiting the function of nuclear factor κB (NFκB) and consequently the transcription of …

The hypothalamic–pituitary–adrenal (HPA) axis is one of the body's neuroendocrine
networks that responds to psychological stress (PS). In the skin, there exists a peripheral …

Glucocorticoids (GCs) are known inhibitors of wound healing. In this study we report the
novel finding that both keratinocytes in vitro and epidermis in vivo synthesize cortisol and …