Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

Significance: Cancer is a complex disease, which not only involves the tumor but its
microenvironment comprising different immune cells as well. Nitric oxide (NO) plays specific …

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

Objective The aim of this study was to characterize the genome‐wide DNA methylation
profile of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis …

Aging is a natural process characterized by the declining ability of the different organs and
tissues to respond to stress, increasing homeostatic imbalance and risk of disease …

Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …

Recent developments in genetics/genomics of osteoarthritis (OA) are discussed to improve
our understanding of OA pathophysiology. The discovery of a novel variant near the NCOA3 …

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Objective To determine whether altered IL8 methylation status is associated with increased
expression of IL8 in human osteoarthritic (OA) chondrocytes. Methods IL8 expression levels …