Geriatric pharmacology: an update

TM Andres, T McGrane… - Anesthesiology …, 2019 - anesthesiology.theclinics.com
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Airway management of the critically ill patient

SF Reynolds, J Heffner - Chest, 2005 - Elsevier
Advances in emergency airway management have allowed intensivists to use intubation
techniques that were once the province of anesthesiology and were confined to the …

Anesthetic management and one-year mortality after noncardiac surgery

TG Monk, V Saini, BC Weldon, JC Sigl - Anesthesia & Analgesia, 2005 - journals.lww.com
IMPLICATIONS: A prospective, longitudinal study of 1-yr postoperative mortality after
noncardiac surgery confirms that comorbidity is the primary predictor and that intraoperative …

Propofol

C Vanlersberghe, F Camu - Modern Anesthetics, 2008 - Springer
The hypnotic agent propofol has pharmacokinetic characteristics that allow for rapid onset
and offset of drug effect and fast elimination from the body. Elderly patients show a greater …

Recent insights into molecular mechanisms of propofol-induced developmental neurotoxicity: implications for the protective strategies

ZJ Bosnjak, S Logan, Y Liu, X Bai - Anesthesia & Analgesia, 2016 - journals.lww.com
November 2016• Volume 123• Number 5 www. anesthesia-analgesia. org 1287 induction
and maintenance of anesthesia and procedural and critical care sedation in children. The …

[HTML][HTML] The effect of burst suppression on cerebral blood flow and autoregulation: a scoping review of the human and animal literature

AZ Siddiqi, L Froese, A Gomez, AS Sainbhi… - Frontiers in …, 2023 - frontiersin.org
Background: Burst suppression (BS) is an electroencephalography (EEG) pattern in which
there are isoelectric periods interspersed with bursts of cortical activity. Targeting BS through …

Propofol for treatment-resistant depression: a pilot study

BJ Mickey, AT White, AM Arp, K Leonardi… - International Journal …, 2018 - academic.oup.com
Background We hypothesized that propofol, a unique general anesthetic that engages N-
methyl-D-aspartate and gamma-aminobutyric acid receptors, has antidepressant properties …

[HTML][HTML] Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner

C Sumi, A Okamoto, H Tanaka, K Nishi, M Kusunoki… - PloS one, 2018 - journals.plos.org
The intravenous anesthetic propofol (2, 6-diisopropylphenol) has been used for the
induction and maintenance of anesthesia and sedation in critical patient care. However, the …

Neuroprotective effects of propofol in acute cerebral injury

C Adembri, L Venturi… - CNS drug …, 2007 - Wiley Online Library
ABSTRACT Propofol (2, 6‐diisopropylphenol) is one of the most popular agents used for
induction of anesthesia and long‐term sedation, owing to its favorable pharmacokinetic …

Down-regulation of microRNA-21 is involved in the propofol-induced neurotoxicity observed in human stem cell–derived neurons

DM Twaroski, Y Yan, JM Olson, ZJ Bosnjak, X Bai - Anesthesiology, 2014 - pubs.asahq.org
Background: Recent studies in various animal models have suggested that anesthetics such
as propofol, when administered early in life, can lead to neurotoxicity. These studies have …