For many years, the ubiquitin-26S proteasome degradation pathway was considered the
primary route for proteasomal degradation. However, it is now becoming clear that proteins …

Immunoproteasomes contain replacements for the three catalytic subunits of standard
proteasomes. In most cells, oxidative stress and proinflammatory cytokines are stimuli that …

Maintenance of protein homeostasis, also referred to as “Proteostasis”, integrates multiple
pathways that regulate protein synthesis, folding, translocation, and degradation. Failure in …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged
proteins influence several intracellular pathways and result in different disorders and …

Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease
that shares several clinical and pathological features with Alzheimer's disease (AD) …

During viral infection, proper regulation of immune responses is necessary to ensure
successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role …

Proteolytic degradation is an essential cellular process which is primarily carried out by the
20S proteasome core particle (CP), a protease of 720 kDa and 28 individual subunits. As a …

Cellular proteins are exposed to oxidative modification and other forms of damage through
oxidative stress and disease, and as a consequence of aging. This oxidative damage results …

Proteasome inhibition is a validated strategy for therapy of multiple myeloma, but this
disease remains challenging as relapses are common, and often associated with increasing …