[HTML][HTML] Defining interactions between the genome, epigenome, and the environment in inflammatory bowel disease: progress and prospects
Recent advances in our understanding of the pathogenesis of inflammatory bowel disease
(IBD) have highlighted the complex interplay between the genome, the epigenome, and the …
(IBD) have highlighted the complex interplay between the genome, the epigenome, and the …
[HTML][HTML] The individuality paradigm: Automated longitudinal activity tracking of large cohorts of genetically identical mice in an enriched environment
Personalized medicine intensifies interest in experimental paradigms that delineate sources
of phenotypic variation. The paradigm of environmental enrichment allows for comparisons …
of phenotypic variation. The paradigm of environmental enrichment allows for comparisons …
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by an
excess of lipids, mainly triglycerides, in the liver and components of the metabolic syndrome …
excess of lipids, mainly triglycerides, in the liver and components of the metabolic syndrome …
Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers
Gene-environment interactions represent the modification of genetic effects by
environmental exposures and are critical for understanding disease and informing …
environmental exposures and are critical for understanding disease and informing …
[HTML][HTML] eQTL studies: from bulk tissues to single cells
An expression quantitative trait locus (eQTL) is a chromosomal region where genetic
variants are associated with the expression levels of specific genes that can be both nearby …
variants are associated with the expression levels of specific genes that can be both nearby …
Education interacts with genetic variants near GJD2, RBFOX1, LAMA2, KCNQ5 and LRRC4C to confer susceptibility to myopia
R Clark, A Pozarickij, PG Hysi, K Ohno-Matsui… - PLoS …, 2022 - journals.plos.org
Myopia most often develops during school age, with the highest incidence in countries with
intensive education systems. Interactions between genetic variants and educational …
intensive education systems. Interactions between genetic variants and educational …
Parent-of-Origin inference for biobanks
Identical genetic variations can have different phenotypic effects depending on their parent
of origin. Yet, studies focusing on parent-of-origin effects have been limited in terms of …
of origin. Yet, studies focusing on parent-of-origin effects have been limited in terms of …
Modeling interaction and dispersion effects in the analysis of gene-by-environment interaction
Genotype-by-environment interaction (GxE) studies probe heterogeneity in response to risk
factors or interventions. Popular methods for estimation of GxE examine multiplicative …
factors or interventions. Popular methods for estimation of GxE examine multiplicative …
Genotype× environment interactions in gene regulation and complex traits
Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …
underlying human phenotypic variation. Technological developments over the past 15 years …
Appraisal of gene-environment interactions in GWAS for evidence-based precision nutrition implementation
R San-Cristobal, J de Toro-Martín, MC Vohl - Current Nutrition Reports, 2022 - Springer
Abstract Purpose of Review This review aims to analyse the currently reported gene-
environment (G× E) interactions in genome-wide association studies (GWAS), involving …
environment (G× E) interactions in genome-wide association studies (GWAS), involving …