Serine metabolism is frequently dysregulated in cancers; however, the benefit that this
confers to tumors remains controversial. In many cases, extracellular serine alone is …

Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human
cancer, resulting in neomorphic enzymes that convert α-ketoglutarate (α-KG) to 2 …

Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid
cell growth and proliferation,. RNA interference (RNAi)-based loss-of-function screening has …

Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which
glucose-derived metabolic fluxes are used for alternative processes is poorly understood …

Although serine metabolism plays a crucial role in the proliferation and survival of tumor
cells, how it supports tumor cell migration remains poorly understood. Phosphoglycerate …

Aims Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite
significant progress in understanding the genetic aetiologies of DCM, the molecular …

Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine
biosynthetic pathway, is genomically amplified in tumors including breast cancer and …

The amino acid l-serine, one of the so-called non-essential amino acids, plays a central role
in cellular proliferation. l-Serine is the predominant source of one-carbon groups for the de …

Brain energy metabolism is often considered as a succession of biochemical steps that
metabolize the fuel (glucose and oxygen) for the unique purpose of providing sufficient ATP …

The de novo synthesis of the amino acid l-serine plays an essential role in the development
and functioning of the central nervous system (CNS). l-Serine displays many metabolic …