Exosomes are nanovesicles that have emerged as a new intercellular communication
system between an intracellular compartment of a donor cell towards the periphery or an …

Mast cells (MC) are widely distributed throughout the body and are common at mucosal
surfaces, a major host–environment interface. MC are functionally and phenotypically …

Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …

▪ Abstract The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also
cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin …

Prostaglandin E2 (PGE2) is a principal mediator of inflammation in diseases such as
rheumatoid arthritis and osteoarthritis. Nonsteroidal anti-inflammatory medications (NSAIDs) …

Calcium signalling in astrocytes couples changes in neural activity to alterations in cerebral
blood flow by eliciting vasoconstriction or vasodilation of arterioles. However, the …

Prostaglandins are involved in a wide variety of physiological and pathophysiological
processes, but the mechanism of prostaglandin release from cells is not completely …

We identified three novel transporters structurally belonging to the organic anion
transporting polypeptide (OATP) family in humans. Since previously known rat oatp1 to 3 do …

Mechanosensing bone osteocytes express large amounts of connexin (Cx) 43, the
component of gap junctions; yet, gap junctions are only active at the small tips of their …

In 1998 we updated earlier descriptions of the largest family of secondary transport carriers
found in living organisms, the major facilitator superfamily (MFS). Seventeen families of …