The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that
orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone …

Sustained hepatic inflammation is an important factor in progression of chronic liver
diseases, including hepatitis C or non-alcoholic steatohepatitis. Liver inflammation is …

Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …

Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-
coupled seven-span transmembrane receptors, are major regulators of cell trafficking and …

The consequences of prostate cancer metastasis remain severe, with huge impact on the
mortality and overall quality of life of affected patients. Despite the convoluted interplay and …

▪ Abstract Chemokines compose a sophisticated communication system used by all our cell
types, including immune cells. Chemokine messages are decoded by specific receptors that …

Cell‐surface receptors acquire information from the extracellular environment and
coordinate intracellular responses. Many receptors do not operate as individual entities, but …

Rationale: Recent studies indicate that tumor-associated macrophages (MΦ) with an M2
phenotype can influence cancer progression and metastasis, but the regulatory pathways …

Chemokines are the largest family of cytokines in human immunophysiology. These proteins
are defined by four invariant cysteines and are categorized based on the sequence around …

The chemokine CXCL12 (SDF-1) and its cell surface receptor CXCR4 were first identified as
regulators of lymphocyte trafficking to the bone marrow. Soon after, the CXCL12/CXCR4 …