Background Traditional classification of diffuse infiltrating gliomas (DIGs) as World Health
Organization (WHO) grades II-IV is based on histological features of a heterogeneous …

Question Should patients with imaging suggestive of low grade glioma (LGG) undergo
observation versus treatment involving a surgical procedure? Target population These …

Object Greater extent of resection (EOR) for patients with low-grade glioma (LGG)
corresponds with improved clinical outcome, yet remains a central challenge to the …

Seizure is a common presenting manifestation and plays an important role in the clinical
presentation and quality of life for patients with low-grade gliomas (LGGs). The authors set …

Brain tumor surgery involves a delicate balance between maximizing the extent of tumor
resection while minimizing damage to healthy brain tissue that is vital for neurological …

Background National guidelines recommend maximal safe resection of low-grade and high-
grade oligodendrogliomas. However, there is no level 1 evidence to support these …

OBJECTIVE: The majority of adults with low-grade gliomas have seizures. Despite the
frequency of seizures as initial symptoms and symptoms of later disease, seizures in relation …

OBJECTIVE The available evidence suggests that the clinical benefits of extended resection
are limited for chemosensitive tumors, such as primary CNS lymphoma. Oligodendroglioma …

Questions 1. What is the optimal role of external beam radiotherapy in the management of
adult patients with newly diagnosed low-grade glioma (LGG) in terms of improving outcome …

Malignant progression of diffuse low-grade glioma (LGG) is a critical event affecting patient
survival; however, the incidence and related factors have been inconsistent in literature …