Exploring bio-inspired nanomaterials (BINMs) and incorporating them into
micro/nanodevices represent a significant development in biomedical applications …

Drug induced liver injury (DILI) is one of the major reasons of drug withdrawal during the
different phases of drug development. The later in the drug development a drug is …

Animal models are considered prime study models for inhalation-like toxicity assessment.
However, in light of animal experimentation reduction (3Rs), we developed and investigated …

The liver produces and stores various nutrients that are necessary for the body and serves
as a chemical plant, metabolizing carbohydrates, fats, hormones, vitamins, and minerals. It is …

Organ-on-chip (OoC) technology is one of the most promising in vitro tools to replace the
traditional animal experiment-based paradigms of risk assessment. However, the use of …

Microfluidics represents a methodology facilitating the manipulation of minute fluid volumes
via microchannels, with wide-ranging applications across biomedical and pharmaceutical …

Liver diseases account for a significant number of deaths worldwide, being largely attributed
to complications of cirrhosis and hepatocellular carcinoma (1). Still, treatment options for …

Organ-on-chip technology is a promising in vitro approach recapitulating human physiology
for the study of responses to drug exposure. Organ-on-chip cell cultures have paved new …

The liver is one of the main organs involved in the metabolism of xenobiotics and a key
organ in toxicity studies. Prior to accessing the hepatocytes, xenobiotics pass through the …

The liver plays a key role in the metabolism of lipoproteins, controlling both production and
catabolism. To accelerate the development of new lipid‐lowering therapies in humans, it is …