Reconstructing the heart using iPSCs: Engineering strategies and applications
Induced pluripotent stem cells (iPSCs) have emerged as a key component of cardiac tissue
engineering, enabling studies of cardiovascular disease mechanisms, drug responses, and …
engineering, enabling studies of cardiovascular disease mechanisms, drug responses, and …
The skeletal muscle fiber: a mechanically sensitive cell
LA Olsen, JX Nicoll, AC Fry - European journal of applied physiology, 2019 - Springer
The plasticity of skeletal muscle, whether an increase in size, change in metabolism, or
alteration in structural properties, is in a continuous state of flux largely dependent upon …
alteration in structural properties, is in a continuous state of flux largely dependent upon …
Engineering microsphere-loaded non-mulberry silk-based 3D bioprinted vascularized cardiac patches with oxygen-releasing and immunomodulatory potential
A hostile myocardial microenvironment post ischemic injury (myocardial infarction) plays a
decisive role in determining the fate of tissue-engineered approaches. Therefore …
decisive role in determining the fate of tissue-engineered approaches. Therefore …
Generation and maturation of human iPSC-derived 3D organotypic cardiac microtissues in long-term culture
Cardiovascular diseases remain the leading cause of death worldwide; hence there is an
increasing focus on developing physiologically relevant in vitro cardiovascular tissue …
increasing focus on developing physiologically relevant in vitro cardiovascular tissue …
Engineering anisotropic human stem cell-derived three-dimensional cardiac tissue on-a-chip
J Veldhuizen, J Cutts, DA Brafman, RQ Migrino… - Biomaterials, 2020 - Elsevier
Despite significant efforts in the study of cardiovascular diseases (CVDs), they persist as the
leading cause of mortality worldwide. Considerable research into human pluripotent stem …
leading cause of mortality worldwide. Considerable research into human pluripotent stem …
Traction force microscopy of engineered cardiac tissues
Cardiac tissue development and pathology have been shown to depend sensitively on
microenvironmental mechanical factors, such as extracellular matrix stiffness, in both in vivo …
microenvironmental mechanical factors, such as extracellular matrix stiffness, in both in vivo …
Mechanotranduction pathways in the regulation of mitochondrial homeostasis in cardiomyocytes
Mitochondria are one of the most important organelles in cardiomyocytes. Mitochondrial
homeostasis is necessary for the maintenance of normal heart function. Mitochondria …
homeostasis is necessary for the maintenance of normal heart function. Mitochondria …
Recent advances in tailoring stimuli-responsive hybrid scaffolds for cardiac tissue engineering and allied applications
To recapitulate bio-physical properties and functional behaviour of native heart tissues,
recent tissue engineering-based approaches are focused on developing smart/stimuli …
recent tissue engineering-based approaches are focused on developing smart/stimuli …
Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients
The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction
coupling, sarcomeric stability and force generation. We previously reported that induced …
coupling, sarcomeric stability and force generation. We previously reported that induced …
Generation and Culture of Cardiac Microtissues in a Microfluidic Chip with a Reversible Open Top Enables Electrical Pacing, Dynamic Drug Dosing and Endothelial …
Cardiovascular disease morbidity has increased worldwide. Organs‐on‐chips and human
pluripotent stem cell (hPSC) technologies aid to overcome some of the limitations in cardiac …
pluripotent stem cell (hPSC) technologies aid to overcome some of the limitations in cardiac …