Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

The female ovary contains a finite number of oocytes, and their release at ovulation
becomes sporadic and disordered with aging and with obesity, leading to loss of fertility …

Fibrosis is a hallmark of aging tissues which often leads to altered architecture and function.
The ovary is the first organ to show overt signs of aging, including increased fibrosis in the …

Cryopreservation of ovarian tissue to preserve the fertility of girls and young women at high
risk of sterility is now widely practiced. Pieces of cryopreserved ovarian cortex can be …

In vitro follicle growth is a potential approach to preserve fertility for young women who are
facing a risk of premature ovarian failure (POF) caused by radiation or chemotherapy. Our …

The mechanical properties and density of natural and synthetic extracellular matrices are
known to affect cellular processes and regulate tissue formation. In this report, these factors …

BACKGROUND Female cancer patients are offered 'banking'of gametes before starting
fertility-threatening cancer therapy. Transplants of fresh and frozen ovarian tissue between …

BACKGROUND Young female adult and adolescent cancer patients facing life-preserving
but fertility-threatening chemo-or radiation-therapy are increasingly seeking options to …

Oxidative stress, generated by excessive reactive oxygen species (ROS) or decreased
antioxidant defenses (and possibly both), is associated with male infertility. Oxidative stress …