Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
EGF receptor trafficking: consequences for signaling and cancer
A Tomas, CE Futter, ER Eden - Trends in cell biology, 2014 - cell.com
The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …
Endosome maturation, transport and functions
CC Scott, F Vacca, J Gruenberg - Seminars in cell & developmental biology, 2014 - Elsevier
Efficient sorting of the material internalized by endocytosis is essential for key cellular
functions and represents a, if not the, major trafficking pathway in mammalian cells …
functions and represents a, if not the, major trafficking pathway in mammalian cells …
Expression and function of the epidermal growth factor receptor in physiology and disease
J Chen, F Zeng, SJ Forrester, S Eguchi… - Physiological …, 2016 - journals.physiology.org
The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …
Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution
A Martinez-Val, DB Bekker-Jensen… - Nature …, 2021 - nature.com
Dynamic change in subcellular localization of signaling proteins is a general concept that
eukaryotic cells evolved for eliciting a coordinated response to stimuli. Mass spectrometry …
eukaryotic cells evolved for eliciting a coordinated response to stimuli. Mass spectrometry …
The EGFR odyssey–from activation to destruction in space and time
When cell surface receptors engage their cognate ligands in the extracellular space, they
become competent to transmit potent signals to the inside of the cell, thereby instigating …
become competent to transmit potent signals to the inside of the cell, thereby instigating …
Can EGFR be a therapeutic target in breast cancer?
Epidermal growth factor receptor (EGFR) is highly expressed in certain cancer types and is
involved in regulating the biological characteristics of cancer progression, including …
involved in regulating the biological characteristics of cancer progression, including …
Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma
A Palamidessi, C Malinverno, E Frittoli, S Corallino… - Nature materials, 2019 - nature.com
During wound repair, branching morphogenesis and carcinoma dissemination, cellular
rearrangements are fostered by a solid-to-liquid transition, known as unjamming. The …
rearrangements are fostered by a solid-to-liquid transition, known as unjamming. The …
Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors
Dynamin, which is encoded by three genes in mammals, is a GTPase implicated in
endocytic membrane fission. Dynamin 1 and 3 are predominantly expressed in brain …
endocytic membrane fission. Dynamin 1 and 3 are predominantly expressed in brain …
Akt-ing up just about everywhere: compartment-specific Akt activation and function in receptor tyrosine kinase signaling
The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …