Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention

O Devinsky, DC Hesdorffer, DJ Thurman… - The Lancet …, 2016 - thelancet.com
Sudden unexpected death in epilepsy (SUDEP) can affect individuals of any age, but is most
common in younger adults (aged 20–45 years). Generalised tonic-clonic seizures are the …

The Wistar Audiogenic Rat (WAR) strain and its contributions to epileptology and related comorbidities: history and perspectives

N Garcia-Cairasco, EHL Umeoka, JAC de Oliveira - Epilepsy & Behavior, 2017 - Elsevier
In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar
Audiogenic Rat (WAR), first introduced to the neuroscience international community more …

Scurrying to understand sudden expected death in epilepsy: insights from animal models

R Li, GF Buchanan - Epilepsy currents, 2019 - journals.sagepub.com
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients
with refractory epilepsy, accounting for up to 17% of deaths in patients with epilepsy. The …

Audiogenic seizure as a model of sudden death in epilepsy: A comparative study between four inbred mouse strains from early life to adulthood

B Martin, G Dieuset, JL Pawluski, N Costet… - …, 2020 - Wiley Online Library
Objective Mouse models of sudden unexpected death in epileptic patients (SUDEP) using
audiogenic seizures (AGS) are valuable because death can occur following a sound …

Pilocarpine-induced status epilepticus is associated with P-glycoprotein induction in cardiomyocytes, electrocardiographic changes, and sudden death

J Auzmendi, B Buchholz, J Salguero, C Cañellas… - Pharmaceuticals, 2018 - mdpi.com
Sudden unexpected death in epilepsy (SUDEP) is the major cause of death in those patients
suffering from refractory epilepsy (RE), with a 24-fold higher risk relative to the normal …

Furthering our understanding of SUDEP: the role of animal models

AP Pansani, DB Colugnati, CA Scorza… - Expert Review of …, 2016 - Taylor & Francis
Sudden and unexpected death in epilepsy (SUDEP) is the most common type of death
among patients with epilepsy. Here, we address the importance of the experimental models …

[HTML][HTML] Epilepsy as a dynamical system, a most needed paradigm shift in epileptology

MFD Moraes, D de Castro Medeiros, FAG Mourao… - Epilepsy & Behavior, 2021 - Elsevier
The idea of the epileptic brain being highly excitable and facilitated to synchronic activity has
guided pharmacological treatment since the early twentieth century. Although tackling …

Increased ACh-associated immunoreactivity in autonomic centers in PTZ kindling model of epilepsy

E Akyüz, Z Doğanyiğit, YN Paudel, E Kaymak, S Yilmaz… - Biomedicines, 2020 - mdpi.com
Experimental and clinical studies of cardiac pathology associated with epilepsy have
demonstrated an impact on the autonomic nervous system (ANS). However, the underlying …

Dorsal raphe nucleus to pre-Bötzinger complex serotonergic neural circuit is involved in seizure-induced respiratory arrest

HX Ma, Q Yu, Y Shen, XT Lian, LY Gu, YL Wang, Q Xu… - Iscience, 2022 - cell.com
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death among
patients with epilepsy. However, the underlying mechanism of SUDEP remains elusive …

[HTML][HTML] The number and periodicity of seizures induce cardiac remodeling and changes in micro-RNA expression in rats submitted to electric amygdala kindling …

AP Pansani, PP Ghazale, EG Dos Santos… - Epilepsy & Behavior, 2021 - Elsevier
Generalized tonic-clonic seizures (GTCS) are the main risk factor for sudden unexpected
death in epilepsy (SUDEP). Also, among the several mechanisms underlying SUDEP there …