The anatomy and physiology of the microcirculation in human skin are complex. Normal
cutaneous microcirculation is organized in two parallel plexuses with capillary loops …

Prostanoids are bioactive lipid mediators and take part in many physiological and
pathophysiological processes in practically every organ, tissue and cell, including the …

Rationale: Group 2 innate lymphoid cells (ILC2s) robustly produce IL-5 and IL-13, cytokines
central to the asthma phenotype; however, the effect of prostaglandin (PG) I2 on ILC2 …

Aims Vascular injury leading to endothelial dysfunction is a characteristic feature of chronic
renal disease, diabetes mellitus, and systemic inflammatory conditions, and predisposes to …

Type 2 diabetes mellitus (T2DM) is characterized by pancreatic islet failure due to loss of β-
cell secretory function and mass. Studies have identified a link between a variance in the …

Abstract Cerebral Cavernous Malformation (CCM) is a cerebrovascular disease of genetic
origin affecting 0.5% of the population and characterized by abnormally enlarged and leaky …

Prostanoids are a group of bioactive lipids that are synthesized de novo from membrane
phospholipid-released arachidonic acid and have diverse functions in normal physiology …

Pioneering work demonstrated that an unstable substance isolated from rabbit and pig
aortas could relax arterial smooth muscle and inhibit platelet aggregation. Since then …

Vascular endothelial injury in diabetes mellitus (DM) is the major cause of vascular disease,
which is closely related to the occurrence and development of a series of vascular …

Abstract Background Aloe-emodin (AE), a natural anthraquinone extract from traditional
Chinese medicinal plants, has been certified to protect against acute myocardial ischemia …