Recent updates on development of protein-tyrosine phosphatase 1B inhibitors for treatment of diabetes, obesity and related disorders
S Singh, AS Grewal, R Grover, N Sharma, B Chopra… - Bioorganic …, 2022 - Elsevier
The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …
Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus
A Kousaxidis, A Petrou, V Lavrentaki… - European Journal of …, 2020 - Elsevier
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …
[HTML][HTML] Exploring protein tyrosine phosphatases (PTP) and PTP-1B inhibitors in management of diabetes mellitus
Type 2 diabetes mellitus (T2D) is a metabolic disorder that knows no boundaries and is
spread across the globe. It is one of the most widely spread metabolic disorder, which has …
spread across the globe. It is one of the most widely spread metabolic disorder, which has …
Structural and molecular insights of protein tyrosine phosphatase 1B (PTP1B) and its inhibitors as anti-diabetic agents
Diabetes mellitus (DM), especially type 2 diabetes mellitus (T2DM), is the most disruptive
metabolic disorder globally affecting human health. To effectively manage this medical …
metabolic disorder globally affecting human health. To effectively manage this medical …
Elemental exchange: Bioisosteric replacement of phosphorus by boron in drug design
Continuous efforts are being directed toward the employment of boron in drug design due to
its advantages and unique characteristics including a plethora of target engagement modes …
its advantages and unique characteristics including a plethora of target engagement modes …
Pyrazoles as novel protein tyrosine phosphatase 1B (PTP1B) inhibitors: An in vitro and in silico study
S Rocha, M Lucas, VLM Silva, PMO Gomes… - International Journal of …, 2021 - Elsevier
Type 2 diabetes mellitus (DM) is a complex chronic disorder and a major global health
problem. Insulin resistance is the primary detectable abnormality and the main characteristic …
problem. Insulin resistance is the primary detectable abnormality and the main characteristic …
MiR-135a-5p suppresses trophoblast proliferative, migratory, invasive, and angiogenic activity in the context of unexplained spontaneous abortion
Y Lu, X Zhang, X Li, L Deng, C Wei, D Yang… - Reproductive Biology …, 2022 - Springer
Background Spontaneous abortions (SA) is amongst the most common complications
associated with pregnancy in humans, and the underlying causes cannot be identified in …
associated with pregnancy in humans, and the underlying causes cannot be identified in …
Protein tyrosine phosphatase 1B inhibitors from the fungus Malbranchea albolutea
From solid rice-based cultures of Malbranchea albolutea, three undescribed ardeemins and
sartoryglabrins analogs were discovered and named alboluteins AC. 1H-Indole-3 …
sartoryglabrins analogs were discovered and named alboluteins AC. 1H-Indole-3 …
Role of non-receptor-type tyrosine phosphatases in brain-related diseases
Y He, D Nan, H Wang - Molecular Neurobiology, 2023 - Springer
The non-receptor protein tyrosine phosphatase is a class of enzymes that catalyze the
dephosphorylation of phosphotyrosines in protein molecules. They are involved in cellular …
dephosphorylation of phosphotyrosines in protein molecules. They are involved in cellular …
Structural bases for hesperetin derivatives: inhibition of protein tyrosine phosphatase 1B, kinetics mechanism and molecular docking study
In the present study, we investigated the structure-activity relationship of naturally occurring
hesperetin derivatives, as well as the effects of their glycosylation on the inhibition of …
hesperetin derivatives, as well as the effects of their glycosylation on the inhibition of …