Fear generalization and anxiety: behavioral and neural mechanisms

JE Dunsmoor, R Paz - Biological psychiatry, 2015 - Elsevier
Fear can be an adaptive emotion that helps defend against potential danger. Classical
conditioning models elegantly describe how animals learn which stimuli in the environment …

Fear one, fear them all: A systematic review and meta-analysis of fear generalization in pathological anxiety

L Fraunfelter, ABM Gerdes, GW Alpers - Neuroscience & Biobehavioral …, 2022 - Elsevier
It is a defining feature of anxiety disorders that fear is elicited by a circumscribed class of
stimuli rather than by only one specific exemplar of that class. Therefore, fear generalization …

The neuronal basis of fear generalization in humans

S Onat, C Büchel - Nature neuroscience, 2015 - nature.com
Organisms tend to respond similarly to stimuli that are perceptually close to an event that
predicts adversity, a phenomenon known as fear generalization. Greater dissimilarity yields …

What is going on around here? Intolerance of uncertainty predicts threat generalization

J Morriss, B Macdonald, CM Van Reekum - PloS one, 2016 - journals.plos.org
Attending to stimuli that share perceptual similarity to learned threats is an adaptive strategy.
However, prolonged threat generalization to cues signalling safety is considered a core …

The neurobiology of human fear generalization: meta-analysis and working neural model

RD Webler, H Berg, K Fhong, L Tuominen… - Neuroscience & …, 2021 - Elsevier
Fear generalization to stimuli resembling a conditioned danger-cue (CS+) is a fundamental
dynamic of classical fear-conditioning. Despite the ubiquity of fear generalization in human …

[HTML][HTML] Gradients of fear: How perception influences fear generalization

D Struyf, J Zaman, D Hermans, B Vervliet - Behaviour research and therapy, 2017 - Elsevier
The current experiment investigated whether overgeneralization of fear could be due to an
inability to perceptually discriminate the initial fear-evoking stimulus from similar stimuli, as …

Perceptual discrimination in fear generalization: Mechanistic and clinical implications

D Struyf, J Zaman, B Vervliet, I Van Diest - Neuroscience & Biobehavioral …, 2015 - Elsevier
For almost a century, Pavlovian conditioning is the imperative experimental paradigm to
investigate the development and generalization of fear. However, despite the rich research …

Threat learning promotes generalization of episodic memory.

F Starita, MCW Kroes, L Davachi… - Journal of …, 2019 - psycnet.apa.org
The ability to generalize from and distinguish between aversive memories and novel
experiences is critical to survival. Previous research has revealed mechanisms underlying …

Modeling trait anxiety: from computational processes to personality

JG Raymond, JD Steele, P Seriès - Frontiers in psychiatry, 2017 - frontiersin.org
Computational methods are increasingly being applied to the study of psychiatric disorders.
Often, this involves fitting models to the behavior of individuals with subclinical character …

Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear

E Manassero, G Concina, MCC Caraig, P Sarasso… - Elife, 2024 - elifesciences.org
Downregulating emotional overreactions toward threats is fundamental for developing
treatments for anxiety and post-traumatic disorders. The prefrontal cortex (PFC) is critical for …