Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

Myofibrillar proteins exist as multiple isoforms that derive from multigene (isogene) families.
Additional isoforms, including products of tropomyosin, myosin light chain 1 fast, troponin T …

This review discusses the structure and properties of the isolated components of troponin,
their interaction, and the mechanisms of regulation of contractile activity of skeletal and …

In skeletal muscle fibers, action potentials elicit contractions by releasing calcium ions
(Ca2+) from the sarcoplasmic reticulum. Experiments on individual mouse muscle fibers …

Actin-activated myosin II motor function powers muscle contraction and nonmuscle cell
motility. The actin-myosin-derived contractility has evolved with a great diversity in different …

Cardiac troponin (cTn) acts as a pivotal regulator of muscle contraction and relaxation and is
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …

Extraction of regulatory proteins from thick and thin filaments of vertebrate striated muscle
has proven to be an important approach in elucidating roles of these proteins in regulating …

In this study we investigated the physiological role of the cardiac troponin T (cTnT) isoforms
in the presence of human slow skeletal troponin I (ssTnI). ssTnI is the main troponin I isoform …

Conclusions There is now a large body of evidence in support of the view that Ca 2+ binding
to the low affinity sites of TnC induces a movement of helices B and C away from helices A …

Troponin plays a central role in regulating the contraction and relaxation of vertebrate
striated muscles. This review focuses on the isoform gene regulation, alternative RNA …