Human schistosomiasis

DG Colley, AL Bustinduy, WE Secor, CH King - The Lancet, 2014 - thelancet.com
Human schistosomiasis—or bilharzia—is a parasitic disease caused by trematode flukes of
the genus Schistosoma. By conservative estimates, at least 230 million people worldwide …

Analysing the eosinophil cationic protein-a clue to the function of the eosinophil granulocyte

J Bystrom, K Amin, D Bishop-Bailey - Respiratory research, 2011 - Springer
Eosinophil granulocytes reside in respiratory mucosa including lungs, in the gastro-intestinal
tract, and in lymphocyte associated organs, the thymus, lymph nodes and the spleen. In …

Immunological and biochemical interplay between cytokines, oxidative stress and schistosomiasis

P Masamba, AP Kappo - International journal of molecular sciences, 2021 - mdpi.com
The host–parasite schistosome relationship relies heavily on the interplay between the
strategies imposed by the schistosome worm and the defense mechanisms the host uses to …

Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis

CD Bourke, N Nausch, N Rujeni… - The Journal of …, 2013 - academic.oup.com
Background. Schistosomiasis elicits cross-regulatory immune responses, but it is unclear
how antihelminthic treatment affects this balance. This study integrates data on 13 cytokines …

Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica

MT Ruiz-Campillo, V Molina Hernandez, A Escamilla… - Scientific reports, 2017 - nature.com
Immune signatures of sheep acutely-infected with Fasciola hepatica, an important pathogen
of livestock and humans were analysed within the peritoneal compartment to investigate …

Schistosoma mansoni Infection Can Jeopardize the Duration of Protective Levels of Antibody Responses to Immunizations against Hepatitis B and Tetanus Toxoid

DK Riner, EM Ndombi, JM Carter… - PLoS neglected …, 2016 - journals.plos.org
Background Schistosomiasis is a disease of major public health importance in sub-Saharan
Africa. Immunoregulation begins early in schistosome infection and is characterized by …

Granulocytes: effector cells or immunomodulators in the immune response to helminth infection?

ET Cadman, RA Lawrence - Parasite immunology, 2010 - Wiley Online Library
Granulocytes are effector cells in defence against helminth infections. We review the current
evidence for the role of granulocytes in protective immunity against different helminth …

Elevated Systemic Levels of Eosinophil, Neutrophil, and Mast Cell Granular Proteins in Strongyloides Stercoralis Infection that Diminish following Treatment

A Rajamanickam, S Munisankar, Y Bhootra… - Frontiers in …, 2018 - frontiersin.org
Infection with the helminth parasite Strongyloides stercoralis (Ss) is commonly clinically
asymptomatic that is often accompanied by peripheral eosinophilia. Granulocytes are …

Maternal, placental and cord blood cytokines and the risk of adverse birth outcomes among pregnant women infected with Schistosoma japonicum in the Philippines

AI Abioye, EA McDonald, S Park, A Joshi… - PLoS neglected …, 2019 - journals.plos.org
Background The objectives of this study were to 1) evaluate the influence of treatment with
praziquantel on the inflammatory milieu in maternal, placental, and cord blood, 2) assess the …

Effect of chemotherapy with praziquantel on the production of cytokines and morbidity associated with schistosomiasis mansoni

P Martins-Leite, G Gazzinelli… - Antimicrobial agents …, 2008 - Am Soc Microbiol
The objective of the present study was to test the hypothesis that treatment of
schistosomiasis mansoni with praziquantel can alter significantly the immune response of …