Transdermal drug delivery presents a less invasive pathway, circumventing the need to pass
through the gastrointestinal tract and liver, thereby reducing drug breakdown, initial …

In the past decades, the striking development of cationic polypeptides and cell-penetrating
peptides (CPPs) tailored for small interfering RNA (siRNA) delivery has been fuelled by the …

Mendelian genetics spark the century‐old revolution in genetic engineering. DNA structural
engineering may well spark a similar revolution in chemistry. The first few man‐made DNA …

Lipid and protein-based delivery systems have long been used to deliver active compounds
such as drugs, genes, and nutraceuticals. These delivery systems are fabricated to …

Nucleic acid therapy is currently the most promising method for treating tumors and genetic
diseases and for preventing infectious diseases. However, the biggest obstacle to this …

RNA interference (RNAi) is a powerful tool capable of targeting virtually any protein without
time-consuming and expensive drug development studies. However, due to obstacles facing …

L-asparaginase is an important therapeutic enzyme that is frequently utilized in the
chemotherapy regimens of adults as well as pediatric patients with acute lymphoblastic …

With the first reports on the possibility of genome editing by Clustered Regularly Interspaced
Short Palindromic Repeats (CRISPR) and CRISPR-associated protein (Cas) 9 surfacing in …

RNA interference (RNAi) has drawn enormous attention as a powerful tool because of its
capability to interfere with mRNA and protein production. However, designing a safe and …

Despite extensive efforts to repurpose approved drugs, discover new small molecules, and
develop vaccines, COVID-19 pandemic is still claiming victims around the world. The current …