Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …

The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …

Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new
treatments for inflammatory diseases. MCC950 is a potent and specific small-molecule …

Asthma is a common chronic respiratory disease affecting more than 300 million people
worldwide. Clinical features of asthma and its immunological and molecular etiology vary …

In this study, we had developed Naringenin‐loaded liquid crystalline nanoparticles (LCNs)
and investigated the anti‐inflammatory and anticancer activities of Naringenin‐LCNs against …

COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …

Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …

The composition of the lung microbiome is increasingly well characterised, with changes in
microbial diversity or abundance observed in association with several chronic respiratory …

Pyroptosis is commonly induced by the gasdermin (GSDM) family and is accompanied by
the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing …