Mortality in schizophrenia-spectrum disorders: recent advances in understanding and management

V Peritogiannis, A Ninou, M Samakouri - Healthcare, 2022 - mdpi.com
Schizophrenia is a life-shortening disease and life expectancy in patients may be 15–20
years shorter than in the general population, with increasing longevity gap over time …

Personalized treatment of glioblastoma: current state and future perspective

A Rončević, N Koruga, A Soldo Koruga, R Rončević… - Biomedicines, 2023 - mdpi.com
Glioblastoma (GBM) is the most aggressive glial tumor of the central nervous system.
Despite intense scientific efforts, patients diagnosed with GBM and treated with the current …

The more, the merrier…? Antipsychotic polypharmacy treatment strategies in schizophrenia from a pharmacology perspective

S Hjorth - Frontiers in Psychiatry, 2021 - frontiersin.org
Antipsychotic polypharmacy/drug combination treatment (APP) is a remarkably common
practice in the schizophrenia context, given the lack of general support in treatment …

Insomnia and related mental health conditions: Essential neurobiological underpinnings towards reduced polypharmacy utilization rates

M Fornaro, C Caiazza, G De Simone, F Rossano… - Sleep Medicine, 2023 - Elsevier
Insomnia represents a significant public health burden, with a 10% prevalence in the
general population. Reduced sleep affects social and working functioning, productivity, and …

Tackling the behavior of cancer cells: molecular bases for repurposing antipsychotic drugs in the treatment of glioblastoma

M Persico, C Abbruzzese, S Matteoni, P Matarrese… - Cells, 2022 - mdpi.com
Glioblastoma (GBM) is associated with a very dismal prognosis, and current therapeutic
options still retain an overall unsatisfactorily efficacy in clinical practice. Therefore, novel …

Melanocytotoxic chemicals and their toxic mechanisms

M Kim, KM Lim - Toxicological Research, 2022 - Springer
Melanocyte cell death can lead to various melanocyte-related skin diseases including
vitiligo and leukoderma. Melanocytotoxic chemicals are one of the most well-known causes …

Dose-dependent QTc interval prolongation under haloperidol and pipamperone in the management of delirium in a naturalistic setting

P Bohny, S Boettger, J Jenewein - Frontiers in Psychiatry, 2023 - frontiersin.org
Objective Delirium is an acute, life-threatening neuropsychiatric disorder frequently
occurring among hospitalized patients. Antipsychotic medications are often recommended …

Spironolactone alleviates schizophrenia-related reversal learning in Tcf4 transgenic mice subjected to social defeat

M Stephan, J Schoeller, FJ Raabe, A Schmitt, A Hasan… - Schizophrenia, 2022 - nature.com
Cognitive deficits are a hallmark of schizophrenia, for which no convincing pharmacological
treatment option is currently available. Here, we tested spironolactone as a repurposed …

Adverse events during pregnancy associated with entecavir and adefovir: new insights from a real-world analysis of cases reported to FDA adverse event reporting …

R Yang, N Yin, Y Zhao, D Li, X Zhang, X Li… - Frontiers in …, 2022 - frontiersin.org
Background: Due to the embryotoxicity found in animal studies and scarce clinical data in
pregnant women, it is still controversial whether entecavir (ETV) and adefovir dipivoxil (ADV) …

Adverse effects of antipsychotics on sleep in patients with schizophrenia. Systematic review and meta-analysis

YE Valencia Carlo, RA Saracco-Alvarez… - Frontiers in …, 2023 - frontiersin.org
Introduction Our objective was to conduct a systematic review and meta-analysis of adverse
effects on sleep in patients with schizophrenia receiving antipsychotic treatment. Methods A …