Potassium ion channels in glioma: From basic knowledge into therapeutic applications

S Younes, N Mourad, M Salla, M Rahal… - Membranes, 2023 - mdpi.com
Ion channels, specifically those controlling the flux of potassium across cell membranes,
have recently been shown to exhibit an important role in the pathophysiology of glioma, the …

Therapeutic targeting of voltage-gated sodium channel NaV1.7 for cancer metastasis

P Pukkanasut, R Jaskula-Sztul, JC Gomora… - Frontiers in …, 2024 - frontiersin.org
This review focuses on the expression and function of voltage-gated sodium channel
subtype NaV1. 7 in various cancers and explores its impact on the metastasis driving cell …

Voltage-Gated Sodium Channel NaV1.7 Inhibitors with Potent Anticancer Activities in Medullary Thyroid Cancer Cells

P Pukkanasut, J Whitt, R Guenter, SE Lynch… - Cancers, 2023 - mdpi.com
Simple Summary Despite the recent advances in the diagnosis and treatment of medullary
thyroid cancer (MTC), it remains an understudied cancer type and continues to …

NaII-Pred: An ensemble-learning framework for the identification and interpretation of sodium ion inhibitors by fusing multiple feature representation

MT Hassan, H Tayara, KT Chong - Computers in Biology and Medicine, 2024 - Elsevier
High-affinity ligand peptides for ion channels are essential for controlling the flow of ions
across the plasma membrane. These peptides are now being investigated as possible …

Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness

I Stejerean‐Todoran, I Bogeski - The EMBO Journal, 2023 - embopress.org
Although ion transporters and channels have been extensively studied over the last couple
of decades, there are still unresolved aspects with regards to their contribution to cancer cell …

SOX11 as a prognostic biomarker linked to m6A modification and immune infiltration in renal clear cell carcinoma

K Wang, X Chen, Y Liu, X Meng… - Translational Cancer …, 2024 - pmc.ncbi.nlm.nih.gov
Background The prognosis for patients with kidney renal clear cell carcinoma (KIRC)
remains unfavorable, and the understanding of SRY-box transcription factor 11 (SOX11) in …

[HTML][HTML] Distinct Host Gene Targets and Mode of Action in the MicroRNA of Nipah Virus from Malaysia and Bangladesh: A Comparative in-silico Based Analysis

N Dsouza, DB Gupta… - … Research Journal (BBRJ), 2023 - journals.lww.com
Background: Since the emergence of the Nipah virus in Malaysia in 1998, two major variants
of the virus, Nipah Virus Malaysian (NiV-M) and NiV Bangladesh (NiV-B) have been …

Cardiac Cross-Reactivity of NaV Autoantibodies in Metastatic Breast Cancer: A Possible Trigger for Sudden Cardiac Death

C Pappone, A Tarantino, D Melgari, M Piccoli… - medRxiv, 2024 - medrxiv.org
Background and Aims Patients with metastatic breast cancer have an increased risk of
sudden cardiac death (SCD) that cannot be fully explained by cardiotoxic treatments. Recent …

Ion transporting proteins and cancer: Progress and perspectives

MBA Djamgoz - Targets of Cancer Diagnosis and Treatment: Ion …, 2022 - Springer
Ion transporting proteins (ITPs) comprise a wide range of ion channels, exchangers, pumps
and ionotropic receptors many of which are expressed in tumours and contribute …

Análisis de expresión diferencial de genes codificantes para canales de sodio dependientes de voltaje en subtipos histológicos de cáncer cervical

AL Cortés Loaiza - 2024 - repositorio.ucaldas.edu.co
Cervical cancer (CaC) ranks fourth in incidence and mortality in the female population
worldwide. This type of cancer is histologically classified according to the region of the cervix …