Tuberculosis (TB) remains a major health problem worldwide. The infectious agent,
Mycobacterium tuberculosis, has a unique ability to survive within the host, alternating …

Abstract α-Hemolysin (Hla) is a self-assembling, channel-forming toxin that is secreted by
Staphylococcus aureus and is central to the pathogenesis of pulmonary, intraperitoneal …

The disturbing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb)
has been driving the scientific community to urgently search for new and efficient …

Abundant mycolic acids are the hallmark of the mycobacterial cell wall. The biosynthesis of
mycolic acids fulfilled by type I (Fas-I) and type II (Fas-II) synthase systems necessitates long …

Abstract α-hemolysin (Hla) is a self-assembling extracellular protein secreted as a soluble
monomer by most Staphylococcus aureus strains and is an essential virulence factor for the …

The efficacy of colistin, the last option against multidrug-resistant (MDR) Gram-negative
bacteria, is severely threatened by the prevalence of plasmid-or chromosome-mediated …

Listeriolysin O (LLO), an essential virulence determinant of Listeria monocytogenes, is a
pore-forming toxin whose primary function is to facilitate cytosolic bacterial replication by …

The emergence and wide spread of multi-drug resistant Staphylococcus aureus (S. aureus)
requires the development of new therapeutic agents with alternative modes of action. Anti …

Three new transition metal complexes of a tridentate Schiff base ligand, H 2 L= N-(2-
hydroxybenzylideneamino) benzamide, were synthesized in the presence of pyridine, 3 …

Alpha-hemolysin (α-HL) is a self-assembling, channel-forming toxin produced by most
Staphylococcus aureus strains as a 33.2-kDa soluble monomer. Upon binding to a …