Introduction Transmission-blocking vaccines (TBV) prevent community spread of malaria by
targeting mosquito sexual stage parasites, a life-cycle bottleneck, and will be used in …

Currently licensed glycoconjugate vaccines are composed of a carbohydrate moiety
covalently linked to a protein carrier. Polysaccharides are T-cell independent antigens able …

SARS-CoV-2 is a viral respiratory pathogen responsible for the current global pandemic and
the disease that causes COVID-19. All current WHO approved COVID-19 vaccines are …

Immunogenic carrier proteins such as the non‐toxic diphtheria toxin variant, cross‐reacting
material 197 (CRM197), are widely used in subunit vaccine formulations to boost …

Vaccines may offer a new treatment strategy for opioid use disorders and opioid-related
overdoses. To speed translation, this study evaluates opioid conjugate vaccines containing …

Fentanyl is a major contributor to the devastating increase in overdose deaths from
substance use disorders (SUD). A vaccine targeting fentanyl could be a powerful …

Abstract During 2020, the COVID-19 pandemic affected almost 10 8 individuals. Quite a
number of vaccines against COVID-19 were therefore developed, and a few recently …

Tetanus toxoid (TTxd), developed over 100 years ago, is a clinically effective, legacy vaccine
against tetanus. Due to the extreme potency of native tetanus toxin, manufacturing and …

This paper gives an overview of conjugate glycovaccines which contain recombinant
diphtheria toxoid CRM197 as a carrier protein. A special focus is given to synthetic methods …

The rapid growth in technological advances and quantity of scientific data over the past
decade has led to several challenges including data storage and analysis. Accurate models …