Reverse engineering Lewy bodies: how far have we come and how far can we go?

MB Fares, S Jagannath, HA Lashuel - Nature Reviews Neuroscience, 2021 - nature.com
Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …

[HTML][HTML] Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports

HA Lashuel - Neurobiology of disease, 2020 - Elsevier
Several lines of evidence from neuropathological studies, human genetics, in vitro
aggregation studies and cellular and animal models support the hypothesis that aSyn plays …

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes

SH Shahmoradian, AJ Lewis, C Genoud, J Hench… - Nature …, 2019 - nature.com
Parkinson's disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are …

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

AL Mahul-Mellier, J Burtscher… - Proceedings of the …, 2020 - National Acad Sciences
Parkinson's disease (PD) is characterized by the accumulation of misfolded and aggregated
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

R Guerrero-Ferreira, NMI Taylor, AA Arteni, P Kumari… - Elife, 2019 - elifesciences.org
Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological
diseases including Parkinson's disease (PD). Previously, we reported the structure of alpha …

Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage

ST Kumar, S Nazarov, S Porta, N Maharjan… - Nature …, 2023 - nature.com
Despite the strong evidence linking the transactive response DNA-binding protein 43 (TDP-
43) aggregation to the pathogenesis of frontotemporal lobar degeneration with TDP-43 …

Regulation of α-synuclein by chaperones in mammalian cells

BM Burmann, JA Gerez, I Matečko-Burmann… - Nature, 2020 - nature.com
Neurodegeneration in patients with Parkinson's disease is correlated with the occurrence of
Lewy bodies—intracellular inclusions that contain aggregates of the intrinsically disordered …

[HTML][HTML] How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using …

ST Kumar, S Jagannath, C Francois… - Neurobiology of …, 2020 - Elsevier
Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy

TE Moors, CA Maat, D Niedieker, D Mona… - Acta …, 2021 - Springer
Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—
including C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn …

O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology

AT Balana, AL Mahul-Mellier, BA Nguyen… - Nature chemical …, 2024 - nature.com
Amyloid-forming proteins such α-synuclein and tau, which are implicated in Alzheimer's and
Parkinson's disease, can form different fibril structures or strains with distinct toxic properties …